Effects of inhibiting inflammatory cell recruitment on fracture healing Treatment with CCR2 antagonist, INCB3344, led to impaired fracture healing compared.

Slides:



Advertisements
Similar presentations
Role of TNF in fracture healing in vivo Addition of rhTNF at the fracture site on days 0 and 1 led to augmented healing, indicated by increased % callus.
Advertisements

Morphology of white adipose tissue and muscle in S1/3 KO mice of different ages Morphology of white adipose tissue and muscle in S1/3 KO mice of different.
Loss of Hdac3 impairs Ar signaling in mouse prostate tissues and has no effect on apoptosis Loss of Hdac3 impairs Ar signaling in mouse prostate tissues.
Reduced scar formation in the injured GM of CCR2−/− mice
Systemic inflammation activates the exosomal machinery in the choroid plexus Systemic inflammation activates the exosomal machinery in the choroid plexus.
Surface distribution of immunogold‐labelled PS I (A–C) and ATP synthase (D–F) complexes. Surface distribution of immunogold‐labelled PS I (A–C) and ATP.
BRD4 expression levels are associated with sensitivity to BET inhibition in NRAS‐mutant melanoma BRD4 expression levels are associated with sensitivity.
HDAC3 regulates AKT phosphorylation
The HDAC3 inhibitor suppresses SPOP‐mutated prostate cancer cell growth The HDAC3 inhibitor suppresses SPOP‐mutated prostate cancer cell growth A22Rv1.
PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection Proportion.
Treatment with p38γ/p38δ inhibitor shows antifungal effects in vivo
Reverse cholesterol transport is enhanced after systemic miR‐33 silencing.C57BL/6 mice (n = 7) were infused i.v. with 5 mpk scrambled or anti‐miR‐33 oligonucleotides.
AAV8‐hAAT‐FGF21 treatment improves liver fibrosis
Mitochondrial targeting of ceramide induces lethal mitophagy in HPV(+) cells Mitochondrial targeting of ceramide induces lethal mitophagy in HPV(+) cells.
Fstl1 promotes cardiac fibroblasts proliferation via the ERK1/2‐dependent pathway Fstl1 promotes cardiac fibroblasts proliferation via the ERK1/2‐dependent.
Metabolic profile of Tfe3 KO mice
Clinical testing of calcineurin inhibitors cyclosporine A and tacrolimus in autoimmune disorders Clinical testing of calcineurin inhibitors cyclosporine.
Stat3 promotes lung fibrosis and collagen synthesis independent of Smad3.A.Masson's trichrome stained sections of lung from gp130wt (wt), Smad3−/− (Smad3−/−),
TFE3 prevents diet‐induced obesity and metabolic syndrome
EGFL7 affected tumor growth and reduced overall survival
KLK7 is involved in the Aβ degradation activity
Expression of PD‐1 on PBMC and malignant exudate T cells
Histological analysis of tumours in PyMT mice with different levels of endotrophin after chemotherapy.A.Endotrophin staining and quantification, showing.
PEX13 is required for Sindbis virophagy but not general autophagy
Loss of Ifnar1 signaling elicits inflammatory processes and angiogenesis in laser‐induced retinal damage Loss of Ifnar1 signaling elicits inflammatory.
Identification of miR‐499 targets
Effect of VEGFA on ALDH+ population maintenance
The BET inhibitor JQ‐1 in combination with the MEK inhibitor PD synergistically impairs cell proliferation and induces apoptosis of NRAS‐mutant.
BET and MEK inhibition synergistically impair cell cycle regulation and activate apoptotic signaling BET and MEK inhibition synergistically impair cell.
IFN‐β ameliorates microgliosis and inhibits choroidal neovascularization IFN‐β ameliorates microgliosis and inhibits choroidal neovascularization AExperimental.
Mitochondrial ceramide is involved in HPV‐E7‐mediated lethal mitophagy
Combination of OTX‐015 and PD does not induce overt toxicity
Lifespan and locomotion defects in adult flies. A,B
SPRY2 deficiency‐induced SRB1 mediates CRPC
PERK activator treatment protects neurite network
Tgf‐β inhibition through losartan effectively relieves inflammation in RDEB AQuantification of Cd11b‐positive cells shows that losartan treatment significantly.
BETi potentiate the efficacy of MEKi in NRAS‐mutant melanoma
Lysozyme expression in isolated Paneth cells and linage tracing of Notch1+ cells Lysozyme expression in isolated Paneth cells and linage tracing of Notch1+
Hdac3 deletion decreases AKT phosphorylation and tumor growth in Pten knockout prostate cancer Hdac3 deletion decreases AKT phosphorylation and tumor growth.
Impaired ECM protein synthesis in infarcted area of S100a4cre+/− × Fstl1flox/flox mice Impaired ECM protein synthesis in infarcted area of S100a4cre+/−
Effects of in vivo Nutlin‐3 treatment on CSC content of Numb− and Numb+ tumors Effects of in vivo Nutlin‐3 treatment on CSC content of Numb− and Numb+
IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice ARepresentative.
Hccs downregulation induces apoptosome‐independent caspase‐9 activation in mitochondria.A–C.TUNEL assays on st30 embryos co‐injected with hccs‐MO and Apaf1‐MO.
Inhibition of NAMPT using the potent inhibitor FK866 sensitizes additional tumour cells to olaparib.A‐E.Sensitivity of the cell lines MDAMB468 (A), SUM149.
Impact of ONX 0914 on abundance and dissemination of monocytes/macrophages during CVB3 infection Impact of ONX 0914 on abundance and dissemination of monocytes/macrophages.
HPV‐E7 targets RB for induction of ceramide‐dependent mitophagy
Lack of RAD51 nuclear foci identifies PARPi‐sensitive PDX tumors
The HDAC3 inhibitor suppresses PTEN‐deficient prostate cancer growth
R1441G‐LRRK2 co‐localizes with Rab10 in the periphery and Rab8 near the nucleus R1441G‐LRRK2 co‐localizes with Rab10 in the periphery and Rab8 near the.
Combined targeting of PCa AR and CCL2/CCR2 axis suppresses tumour growth and reduces metastasis in a xenograft mouse PCa model Proliferation assay of TRAMP‐C1.
NOD2 deletion exacerbates diet‐induced bacterial translocation, inflammation, and impairs insulin action in the liver A–CQuantification of bacterial DNA.
Calcineurin inhibition impairs neutrophil recruitment in a zebrafish model of invasive aspergillosisAt 2 days post‐fertilization (dpf), Lyz:dsRed or mpx:GFP.
I.c.v.‐injected AβOs induce increased food intake, hypothalamic expression of orexigenic neuropeptides but no hypothalamic cell degeneration AAccumulated.
Both the number and the OX40L expression level of bronchiolar progenitors were increased by influenza infection. Wild‐type mice were intratracheally infected.
Therapeutic role of TR in HFD‐established diabetic mice
Rescue of motor neurons from death The ventral root of the fifth lumbar segment (L5). Rescue of motor neurons from death The ventral root of the fifth.
Lipid presentation by CD11c+ cells controls iNKT cell subsets
Growth of TKI‐resistant EGFR delE746‐A750 PC‐9 NSCLC cells is associated with elevated cellular free fatty acid and expression of FASN, and is suppressed.
Prazosin inhibits GIC survival
Etifoxine modulation of T‐cell activity during EAE
Histological and mRNA analysis of the inflammatory cytokines in the vehicle‐ or etifoxine‐treated mice at onset of clinical symptoms.A–D.At day 10 p.i.,
PKAN human neurons show altered oxidative status
P2Y1 receptor mediated the directional migration of SVZ neuroblasts in an EF. (A) Suramin (general purinergic receptor inhibitor, 5 μM) did not affect.
Effect of D‐Asp treatment on myelination and remyelination in cerebellar organotypic slices Effect of D‐Asp treatment on myelination and remyelination.
PRG‐1R346T: loss‐of‐function mutation reduced LPA internalization due to altered O‐glycosylation PRG‐1R346T: loss‐of‐function mutation reduced LPA internalization.
CNP520 treatment of male C57/BL6 mice for 8 weeks did not cause hair depigmentation CNP520 treatment of male C57/BL6 mice for 8 weeks did not cause hair.
Bevacizumab therapy leads to reduced vessel density and increased Ang‐2 expression Bevacizumab therapy leads to reduced vessel density and increased Ang‐2.
Bazedoxifene suppresses IL11‐mediated STAT3 signaling activity in human cancer cell lines and patient‐derived colon cancer primary cultures and organoids.
SEMA3C regulates prostate cancer cell growth
Niacin suppresses pro‐inflammatory cytokine expression in macrophages in DSS‐induced colitis in mice Niacin suppresses pro‐inflammatory cytokine expression.
Presentation transcript:

Effects of inhibiting inflammatory cell recruitment on fracture healing Treatment with CCR2 antagonist, INCB3344, led to impaired fracture healing compared to vehicle control as shown by the reduced % callus mineralization at day 28 after operation. Effects of inhibiting inflammatory cell recruitment on fracture healing Treatment with CCR2 antagonist, INCB3344, led to impaired fracture healing compared to vehicle control as shown by the reduced % callus mineralization at day 28 after operation. Data are presented as mean ± SEM. *P = 0.011 unpaired two‐sided t‐test. Representative micro‐CT images are shown. Scale bar, 2 mm. James K Chan et al. EMBO Mol Med. 2015;7:547-561 © as stated in the article, figure or figure legend