Feasibility of Magnetic Resonance Imaging–guided Focused Ultrasound Surgery as an Adjunct to Tamoxifen Therapy in High-risk Surgical Patients with Breast.

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Feasibility of Magnetic Resonance Imaging–guided Focused Ultrasound Surgery as an Adjunct to Tamoxifen Therapy in High-risk Surgical Patients with Breast Carcinoma David Gianfelice, MD, Abdesslem Khiat, PhD, Yvan Boulanger, PhD, Mourad Amara, DES, Assia Belblidia, MD Journal of Vascular and Interventional Radiology Volume 14, Issue 10, Pages 1275-1282 (October 2003) DOI: 10.1097/01.RVI.0000092900.73329.A2 Copyright © 2003 Society of Interventional Radiology Terms and Conditions

Figure 1 Sche-matic diagram demonstrating patient in prone position and MR imaging–guided focused US sur-gery equipment. Journal of Vascular and Interventional Radiology 2003 14, 1275-1282DOI: (10.1097/01.RVI.0000092900.73329.A2) Copyright © 2003 Society of Interventional Radiology Terms and Conditions

Figure 2 Table insert situated in MR apparatus, which houses a 10-cm transducer (arrowhead) and a series of pistons that allow transducer displacement (straight arrows). Journal of Vascular and Interventional Radiology 2003 14, 1275-1282DOI: (10.1097/01.RVI.0000092900.73329.A2) Copyright © 2003 Society of Interventional Radiology Terms and Conditions

Figure 3 Fast gradient-recall echo coronal image (TR, 22.4 msec; TE, 10.6 msec) demonstrating a small, stellate biopsyproven breast carcinoma (arrow), with the area to be treated defined by a computergenerated circle (curved arrow). Journal of Vascular and Interventional Radiology 2003 14, 1275-1282DOI: (10.1097/01.RVI.0000092900.73329.A2) Copyright © 2003 Society of Interventional Radiology Terms and Conditions

Figure 4 Complex gradient-recall echo image with phase subtraction (TR, 38 msec; TE, 4 msec; flip angle, 45°) demonstrating a hyperintense area (arrow) after a single-point treatment, indicating thermal damage in the treatment area. Journal of Vascular and Interventional Radiology 2003 14, 1275-1282DOI: (10.1097/01.RVI.0000092900.73329.A2) Copyright © 2003 Society of Interventional Radiology Terms and Conditions

Figure 5 (a) Pretreatment coronal T1-weighted image (TR, 500 msec; TE, 14 msec) demonstrating an easily visible small stellate breast carcinoma (arrow) surrounded by fatty tissue. (b) Posttreatment coronal T1-weighted image of the same patient (TR, 500 msec; TE, 14 msec) without contrast material infusion demonstrates MR imaging–guided focused US surgery treatment margin (arrow), which represents destruction of the fatty tissue surrounding the treated neoplasm (curved arrow). (c) Posttreatment sagittal T1-weighted image from the same patient demonstrates treatment margin (arrow) surrounding the centrally located breast neoplasm (curved arrow). Journal of Vascular and Interventional Radiology 2003 14, 1275-1282DOI: (10.1097/01.RVI.0000092900.73329.A2) Copyright © 2003 Society of Interventional Radiology Terms and Conditions