Myocardial functional recovery after fibroblast growth factor 2 gene therapy as assessed by echocardiography and magnetic resonance imaging Keith A Horvath,

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Presentation transcript:

Myocardial functional recovery after fibroblast growth factor 2 gene therapy as assessed by echocardiography and magnetic resonance imaging Keith A Horvath, MD, John Doukas, PhD, Chia-Yang J Lu, MD, Noam Belkind, Rodney Greene, BS, Glenn F Pierce, PhD, MD, David A Fullerton, MD The Annals of Thoracic Surgery Volume 74, Issue 2, Pages 481-487 (August 2002) DOI: 10.1016/S0003-4975(02)03736-0

Fig 1 Region contractility as assessed by epicardial echocardiography of the ischemic myocardium for both groups. Six weeks after adenovirus vector-fibroblast growth factor 2 gene-activated matrix (AdFGF2 GAM) treatment there was a significant improvement in wall thickening versus baseline and versus untreated control animals (p < 0.05). (Tx = therapy.) The Annals of Thoracic Surgery 2002 74, 481-487DOI: (10.1016/S0003-4975(02)03736-0)

Fig 2 Results of magnetic resonance imaging data demonstrate a significant improvement in contractility in the ischemic myocardium 6 weeks after adenovirus vector-fibroblast growth factor 2 gene-activated matrix (AdFGF2 GAM) treatment (p < 0.05). The nonischemic (normal) myocardium and the ischemic control (untreated) areas showed no significant improvement with time. The Annals of Thoracic Surgery 2002 74, 481-487DOI: (10.1016/S0003-4975(02)03736-0)

Fig 3 Arteriogenesis as determined by vessel wall area with anti-α-actin immunohistochemical staining 6 weeks after randomization. There is a significant difference in arteriogenesis in the ischemic areas between the adenovirus vector-fibroblast growth factor 2 gene-activated matrix (AdFGF2 GAM) treated animals and the untreated control animals (p < 0.05). The arteriolar wall area after treatment was also significantly greater than that seen in the nonischemic (normal) myocardium for either group (p < 0.05). The Annals of Thoracic Surgery 2002 74, 481-487DOI: (10.1016/S0003-4975(02)03736-0)

Fig 4 Vascular development in control and gene therapy-treated animals. Representative images taken from the ischemic zone of control (A and B) or matrix-formulated adenovirus vector-fibroblast growth factor 2-treated (C–F) animals. All images were taken at the same original magnification (×200); A, C, and E show trichrome-stained sections, and B, D, and F show the same area in a parallel section stained by anti-α-actin immunohistochemistry. C and D represent a different animal than E and F. The Annals of Thoracic Surgery 2002 74, 481-487DOI: (10.1016/S0003-4975(02)03736-0)