The Role of Diffusion-Weighted Magnetic Resonance Imaging in the Treatment Response Evaluation of Hepatocellular Carcinoma Patients Treated With Radiation.

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The Role of Diffusion-Weighted Magnetic Resonance Imaging in the Treatment Response Evaluation of Hepatocellular Carcinoma Patients Treated With Radiation Therapy Jeong Il Yu, MD, Hee Chul Park, MD, Do Hoon Lim, MD, Yunseon Choi, MD, Sang Hoon Jung, PhD, Seung Woon Paik, MD, Seong Hyun Kim, MD, Woo Kyoung Jeong, MD, Young Kon Kim, MD International Journal of Radiation Oncology • Biology • Physics Volume 89, Issue 4, Pages 814-821 (July 2014) DOI: 10.1016/j.ijrobp.2014.03.020 Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 1 Region of interest (ROI) drawing on an apparent diffusion coefficient (ADC) map. Two radiation oncologists measured ADC values of target hepatocellular carcinoma (HCC) in reference to other diffusion images. International Journal of Radiation Oncology • Biology • Physics 2014 89, 814-821DOI: (10.1016/j.ijrobp.2014.03.020) Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 2 Local progression-free survival (LPFS) according to each response criteria. Modified response evaluation criteria in solid tumors (mRECIST) was the most significant factor for LPFS, but diffusion-weighted (DW) RECIST displayed comparable results. International Journal of Radiation Oncology • Biology • Physics 2014 89, 814-821DOI: (10.1016/j.ijrobp.2014.03.020) Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 3 Receiver operating curve analysis for local progression (LP). Area under the curve value was highest in modified response evaluation criteria in solid tumors (mRECIST) but was also comparable in diffusion-weighted (DW) RECIST. International Journal of Radiation Oncology • Biology • Physics 2014 89, 814-821DOI: (10.1016/j.ijrobp.2014.03.020) Copyright © 2014 Elsevier Inc. Terms and Conditions