Antiproliferative and apoptotic effects of rofecoxib on esophageal cancer in vitro1 Linda Vona-Davis, Ph.D., Dale R Riggs, Barbara J Jackson, David W.

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Antiproliferative and apoptotic effects of rofecoxib on esophageal cancer in vitro1 Linda Vona-Davis, Ph.D., Dale R Riggs, Barbara J Jackson, David W McFadden, M.D. Journal of Surgical Research Volume 119, Issue 2, Pages 143-148 (June 2004) DOI: 10.1016/j.jss.2004.03.014

FIG. 1 Catechin, a specific COX-1 inhibitor, reduces cell growth in two human squamous cell carcinoma (SCC) cell lines of the esophagus, KYSE 410 and KYSE 150. The graph depicts dose dependence when the SCC cells were treated with Catechin. Data shown are means ± standard deviations. Asterisks indicate statistical significance versus the nontreatment control. Journal of Surgical Research 2004 119, 143-148DOI: (10.1016/j.jss.2004.03.014)

FIG. 2 NS398, an experimental COX-2 inhibitor, reduces cell growth in two human SCC cell lines, KYSE 410 and KYSE 150. The graph depicts dose dependence when the SCC cancer cells are treated with NS398. Data shown are means ± standard deviations. Asterisks indicate statistical significance versus the nontreatment control. Journal of Surgical Research 2004 119, 143-148DOI: (10.1016/j.jss.2004.03.014)

FIG. 3 Catechin, a specific COX-1 inhibitor, reduces cell growth in two human Barrett’s adenocarcinoma (BA) cell lines (SEG-1 and BIC). The graph depicts the time course and dose dependence when BA cells were treated with Catechin. Data shown are means ± standard deviations. Asterisks indicate statistical significance versus the nontreatment control. Journal of Surgical Research 2004 119, 143-148DOI: (10.1016/j.jss.2004.03.014)

FIG. 4 NS398, an expeirmental COX-2 inhibitor, reduces cell growth in two human BA cell lines (SEG-1 and BIC). The graph depicts the time course and dose dependence when BA cells were treated with Catechin. Data shown are means ± standard deviations. Asterisks indicate statistical significance versus the nontreatment control. Journal of Surgical Research 2004 119, 143-148DOI: (10.1016/j.jss.2004.03.014)

FIG. 5 Apoptotic activity, determined by the annexin V assay, did not produce any significant changes in early or late apoptosis in the KYSE 150 cell line. The graph summarizes apoptotic activity in the presence of Catechin (a COX-1 inhibitor) and NS398 (a COX-2 inhibitor). Data shown are means ± standard deviations. Asterisks indicate statistical significance versus the nontreatment control. Journal of Surgical Research 2004 119, 143-148DOI: (10.1016/j.jss.2004.03.014)

FIG. 6 Apoptotic activity, determined by the annexin V assay, induces early and late apoptosis in the KYSE 410 cell line. The graph summarizes apoptotic activity in the presence of Catechin (a COX-1 inhibitor) and NS398 (a COX-2 inhibitor). Data shown are means ± standard deviations. Asterisks indicate statistical significance versus the nontreatment control. Journal of Surgical Research 2004 119, 143-148DOI: (10.1016/j.jss.2004.03.014)

FIG. 7 Apoptotic activity, determined by the annexin V assay, induces early apoptosis, but reduces late apoptosis in the BIC cell line. The graph summarizes apoptotic activity in the presence of Catechin (a COX-1 inhibitor) and NS398 (a COX-2 inhibitor). Data shown are means ± standard deviations. Asterisks indicate statistical significance versus the nontreatment control. Journal of Surgical Research 2004 119, 143-148DOI: (10.1016/j.jss.2004.03.014)

FIG. 8 Apoptotic activity, determined by the annexin V assay, induces early and late apoptosis in the SEG-1 cell line. The graph summarizes apoptotic activity in the presence of Catechin (a COX-1 inhibitor) and NS398 (a COX-2 inhibitor). Data shown are means ± standard deviations. Asterisks indicate statistical significance versus the nontreatment control. Journal of Surgical Research 2004 119, 143-148DOI: (10.1016/j.jss.2004.03.014)