Volume 146, Pages (October 2016)

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Volume 146, Pages 51-55 (October 2016) Impact of genetic variation in the 5-HT transporter and receptor on platelet function in patients with stable CAD taking aspirin Dr Amrit Bajrangee, Mbchb, MRCPI, MRCPUK, Dr Nicola Ryan, Mbchb, MRCPI, Dr Ciara Vangjeli, PhD, Dr Marian Brennan, PhD, Dr Dermot Cox, PhD, Professor Denis C. Shields, PhD, Professor Desmond Fitzgerald, PhD, Dr Andrew Maree, Mbchb, MRCPI, PhD Thrombosis Research Volume 146, Pages 51-55 (October 2016) DOI: 10.1016/j.thromres.2016.08.019 Copyright © 2016 Elsevier Ltd Terms and Conditions

Fig. 1 Sequences provided for genotyping of the 5-HT receptor and transporter variant data in fasta format. The human serotonin 2A receptor gene (5HTR2A) gene variant 1354C>T is highlighted in yellow in A. This is a synonymous SNP translating to the amino acid change His452Tyr. The human serotonin transporter (5-HTT; SLC6A4) gene variant (5-HTTLPR) is depicted in B. This gene carries a 44bp insertion/deletion promoter polymorphism (−1440 to −1396) indicated in red. Thrombosis Research 2016 146, 51-55DOI: (10.1016/j.thromres.2016.08.019) Copyright © 2016 Elsevier Ltd Terms and Conditions

Fig. 2 Patients with the LL phenotype for the 5-HTT gene have increased serum TXB2 level by 5-HTTLPR genotype. Serum TX (ng/ml) on the y-axis and genotype on the x-axis. Thrombosis Research 2016 146, 51-55DOI: (10.1016/j.thromres.2016.08.019) Copyright © 2016 Elsevier Ltd Terms and Conditions

Fig. 3 The 5-HTTLPR genotype is associated with TXB2 levels >2.2ng/ml. Patients with elevated serum TXB2 levels (TX>2.2ng/ml) are indicated in blue. Numbers of patients on the y-axis and genotype on the x-axis. Thrombosis Research 2016 146, 51-55DOI: (10.1016/j.thromres.2016.08.019) Copyright © 2016 Elsevier Ltd Terms and Conditions

Fig. 4 The 5-HTTLPR genotype is associated with elevated TXB2 levels in patients over 64years. Patients (a) <64years and (b) ≥64years with elevated serum TXB2 levels (TX>2.2ng/ml in blue) by 5-HTTLPR genotype. Numbers of patients on the y-axis and genotype on the x-axis. Thrombosis Research 2016 146, 51-55DOI: (10.1016/j.thromres.2016.08.019) Copyright © 2016 Elsevier Ltd Terms and Conditions

Fig. 5 The 5-HTTLPR genotype is not associated with an increased level of arachidonic acid-induced platelet aggregation. Increased AA aggregation by 5-HTTLPR genotype (AA aggregation >20% in blue). Thrombosis Research 2016 146, 51-55DOI: (10.1016/j.thromres.2016.08.019) Copyright © 2016 Elsevier Ltd Terms and Conditions