Urokinase treatment preserves endothelial and smooth muscle function in experimental acute arterial thrombosis David Whitley, MD, Peter Gloviczki, MD,

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Presentation transcript:

Urokinase treatment preserves endothelial and smooth muscle function in experimental acute arterial thrombosis David Whitley, MD, Peter Gloviczki, MD, Robert Rhee, MD, Henry D. Tazelaar, MD, Virginia Miller, PhD Journal of Vascular Surgery Volume 23, Issue 5, Pages 851-859 (May 1996) DOI: 10.1016/S0741-5214(96)70248-3 Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Diagram demonstrating method of controlled balloon catheter thrombectomy. Linear shear is measured with force transducer. Linear shear is kept close to 60 grams by controlling balloon inflation during catheter withdrawal. Journal of Vascular Surgery 1996 23, 851-859DOI: (10.1016/S0741-5214(96)70248-3) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Contraction-response curves to phenylephrine (PE) (1 ×10-6) and potassium chloride (KCI) (60 mmol/L) in femoral arterial rings with intact endothelium. Data are mean ± SEM of change in tension (grams). Responses of rings without endothelium (not shown) were not different from those with endothelium. Contraction of balloon-thrombectomized rings was significantly decreased (p < 0.05) compared with other groups. Journal of Vascular Surgery 1996 23, 851-859DOI: (10.1016/S0741-5214(96)70248-3) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Contraction-response curves to acetylcholine in femoral arterial rings with intact endothelium. Data are mean ± SEM of percent change in tension from contraction to phenylephrine (1 × 10-6 mol/L). Relaxation of balloon-thrombectomized rings was significantly decreased (p < 0.001) compared with groups 2, 3, and 4. Journal of Vascular Surgery 1996 23, 851-859DOI: (10.1016/S0741-5214(96)70248-3) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Contraction-response curves to bradykinin in femoral arterial rings with intact endothelium. Data are mean ± SEM of percent change in tension from contraction to phenylephrine (1 × 10-6 mol/L). Relaxation of balloon thrombectomized rings was significantly decreased (p < 0.001 for group 1 vs all other groups) compared with all other groups. Journal of Vascular Surgery 1996 23, 851-859DOI: (10.1016/S0741-5214(96)70248-3) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 5 Contraction-repsonse curves to thrombin in femoral arterial rings with intact endothelium. Data are mean ± SEM of percent change in tension from contraction to phenylephrine (1 × 10-6 mol/L). Relaxation of ballon-thrombectomized rings was significantly decreased (p < 0.001) compared with all other groups. Journal of Vascular Surgery 1996 23, 851-859DOI: (10.1016/S0741-5214(96)70248-3) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 6 Contraction-response curves to calcium ionophore A23187 in femoral arterial rings with intact endothelium. Data are mean ± SEM of percent change in tension from contraction to endothelin-1 (1 × 10-7 mol/L). Balloon-thrombectomized rings paradoxically contracted (p < 0.001) compared with all other groups. Journal of Vascular Surgery 1996 23, 851-859DOI: (10.1016/S0741-5214(96)70248-3) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions