Skeletal Muscle Metabolism in the Chronic Fatigue Syndrome

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Skeletal Muscle Metabolism in the Chronic Fatigue Syndrome Roger Wong, M.D., Gary Lopaschuk, Ph.D., Gang Zhu, Ph.D., Dorothy Walker, B.Sc., RN, Dianne Catellier, B.Sc., David Burton, Koon Teo, M.D., Ph.D., Ruth Collins-Nakai, M.D., Terrence Montague, M.D. CHEST Volume 102, Issue 6, Pages 1716-1722 (December 1992) DOI: 10.1378/chest.102.6.1716 Copyright © 1992 The American College of Chest Physicians Terms and Conditions

Figure 1 The in vivo phosphorus 31 nuclear magnetic resonance spectra of the right gastrocnemius muscle of a chronic fatigue syndrome (CFS) patient (patient 1; Table 1), at rest (top panel) and at peak exercise or clinical fatigue (bottom panel), a=inorganic phosphate peak; b=phosphocreatine; c=gamma, d=alpha, and e=beta components of adenosine triphosphate. Note the unit concentration scale in the upper panel is 10 times greater than the scale of the lower panel. CHEST 1992 102, 1716-1722DOI: (10.1378/chest.102.6.1716) Copyright © 1992 The American College of Chest Physicians Terms and Conditions

Figure 2 The temporal patterns of intracellular phosphocreatine (PCr) in the normal subjects (circles) and chronic fatigue syndrome (CFS) patients (squares). Each data point represents the respective group mean PCr value at, successively, from left to right: preexercise rest (first two points); 25 percent, 50 percent, and 75 percent of exercise duration; peak exercise or exhaustion (closed data points); and each minute of postexercise recovery. CHEST 1992 102, 1716-1722DOI: (10.1378/chest.102.6.1716) Copyright © 1992 The American College of Chest Physicians Terms and Conditions

Figure 3 The group mean temporal patterns of intracellular inorganic phosphate (Pi) in the normal subjects (circles) and chronic fatigue syndrome (CFS) patients (squares) from rest to recovery. The format is the same as Figure 2. CHEST 1992 102, 1716-1722DOI: (10.1378/chest.102.6.1716) Copyright © 1992 The American College of Chest Physicians Terms and Conditions

Figure 4 The group mean temporal patterns of energy cost index (ECI) in the normal subjects (circles) and chronic fatigue syndrome (CFS) patients (squares) from rest to recovery. The format is the same as Figures 2 and 3. CHEST 1992 102, 1716-1722DOI: (10.1378/chest.102.6.1716) Copyright © 1992 The American College of Chest Physicians Terms and Conditions

Figure 5 The group mean temporal patterns of pH in the normal subjects (circles) and chronic fatigue syndrome (CFS) patients (squares) from rest to recovery. The format is the same as Figures 2 to 4. CHEST 1992 102, 1716-1722DOI: (10.1378/chest.102.6.1716) Copyright © 1992 The American College of Chest Physicians Terms and Conditions