Volume 35, Issue 4, Pages 826-834 (August 2016) Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial  Jesus Castro-Marrero, Naia Sáez-Francàs, María Jose Segundo, Natalia Calvo, Mónica Faro, Luisa Aliste, Tomás Fernández de Sevilla, Jose Alegre  Clinical Nutrition  Volume 35, Issue 4, Pages 826-834 (August 2016) DOI: 10.1016/j.clnu.2015.07.010 Copyright © 2015 The Authors Terms and Conditions

Fig. 1 Flowchart of the study participants. Consolidated Standards of Reporting Trials (CONSORT) flow diagram showing the distribution of the participants from initial assessment to analysis of study data. CFS, Chronic Fatigue Syndrome; CoQ10, Coenzyme Q10; NADH, reduced nicotinamide adenine dinucleotide. Clinical Nutrition 2016 35, 826-834DOI: (10.1016/j.clnu.2015.07.010) Copyright © 2015 The Authors Terms and Conditions

Fig. 2 The changes in participants treated with CoQ10 + NADH or placebo were determined on the basis of the changes in max HR during the cycle ergometer test from baseline to week 8. More negative scores indicate more diminishment of the max HR value from baseline. Clinical Nutrition 2016 35, 826-834DOI: (10.1016/j.clnu.2015.07.010) Copyright © 2015 The Authors Terms and Conditions

Fig. 3 Changes in FIS scoring during each follow-up visits. Each point on the curve indicates mean FIS scoring. Lower scores means an improvement in the fatigue perception. No significant differences in all the FIS scores were observed between both intervention groups in each study visits. Clinical Nutrition 2016 35, 826-834DOI: (10.1016/j.clnu.2015.07.010) Copyright © 2015 The Authors Terms and Conditions