François Tremblay, Jenna Waterhouse, Janette Nason, Wilhelmina Kalt

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Date of download: 11/13/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Spectral-Domain Optical Coherence Tomographic Characteristics.

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Prophylactic neuroprotection by blueberry-enriched diet in a rat model of light-induced retinopathy François Tremblay, Jenna Waterhouse, Janette Nason, Wilhelmina Kalt Journal of Nutritional Biochemistry Volume 24, Issue 4, Pages 647-655 (April 2013) DOI: 10.1016/j.jnutbio.2012.03.011 Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 1 Intensity–response curves of electroretinographic data obtained in (A, B) scotopic and (C, D) photopic conditions, for the (A, C) W rats and the (B, D) BN rats, in control conditions (open square) and 6 days post-LIRD in conditions of gavage with PL (open circle), BBED 2 weeks (gray circles) and BBED 7 weeks (black circles). Bars are standard deviation. Best fit curves for each group are described in the text. Journal of Nutritional Biochemistry 2013 24, 647-655DOI: (10.1016/j.jnutbio.2012.03.011) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 2 Comparison between the maximum amplitude parameter of the Naka–Rushton equation (Vmax) in control (n=4) condition and after LIRD that was preceded by 4 weeks of BBED (BBED 4W; black bar, n=3) or placebo (PL; gray bar, n=4) in a W rat subgroup. When the BBED was initiated after the LIRD (BBED post-LIRD; hatched bar, n=4), no neuroprotection effect was observed. Bars are mean±S.D. Stars indicate P<.05 as per ANOVA analysis after Bonferroni post hoc corrections. Journal of Nutritional Biochemistry 2013 24, 647-655DOI: (10.1016/j.jnutbio.2012.03.011) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 3 Representative histological section from inferior and superior hemiretina, 1 mm from the optic nerve head, for the W (top row) and BN (bottom row) rats in control conditions (first column) and 11 days after light insult in animals fed with PL (second column), 7-week BBED (third column) and 2-week BBED (fourth column). Scaling as indicated. OPL: outer plexiform layer; INL: inner nuclear layer; IPL: inner plexiform layer; GC: ganglion cell layer. Journal of Nutritional Biochemistry 2013 24, 647-655DOI: (10.1016/j.jnutbio.2012.03.011) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 4 Structure–function correlations in the W rats. (A) Bar graph showing the relative percentage of outer nuclear layer categorized by number of cell rows in the superior and inferior hemiretinae of PL group (n=9) and BBED 7W and BBED 2W groups (n=5 and 4, respectively) (mean ± S.D.). (B) Correlation between functional loss (b-wave amplitude loss in percentage of control) and histological changes (attenuation of ONL thickness in percentage of retinal section with six rows of cells or more) in a subgroup of W rats gavaged with PL (open circles), BBED 2W (gray circles) and BBED 7W (black circles). The line is a linear regression fitted to the PL data. Journal of Nutritional Biochemistry 2013 24, 647-655DOI: (10.1016/j.jnutbio.2012.03.011) Copyright © 2013 Elsevier Inc. Terms and Conditions