Nanomedicine Research at OU

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Presentation transcript:

Nanomedicine Research at OU Roger Harrison, Ph.D. Professor School of Biomedical Engineering School of Chemical, Biological and Materials Engineering OU Health Sciences Center Biomedical Engineering Symposium March 24, 2017

What Is Nanomedicine? Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials and biological devices, to nanoelectronic biosensors, and even future applications of molecular nanotechnogy such as biological machines. Current problems for nanomedicine involve understanding the issues related to toxicity and environmental impact of nanoscale materials. Distinct from the field of Molecular Medicine, a broad field where physical, chemical, biological, bioinformatics and medical techniques are used to describe molecular structures and mechanisms, identify fundamental molecular and genetic errors of disease, and to develop molecular interventions to correct them.

Nanomedicine Researchers at OU OU-Norman - include: Michael Detamore – Biomedical Engineering Nanoparticles in tissue engineering Roger Harrison – Biomedical Engineering, and Chemical, Biological and Materials Engineering Targeted single-walled carbon nanotubes for photothermal therapy of cancer and targeted gold nanoparticles for imaging tumors Chaunbin Mao – Chemistry and Biochemistry Phage nanomedicine for various applications Vassilios Sikavitsas – Biomedical Engineering Nano- and micro-scale features of tissue scaffolds for tissue engineering

Nanomedicine Researchers at OU OU Health Sciences Center - include: Priyabrata Mukherjee – Pathology and Stephenson Cancer Center Nanoparticles for cancer therapy, including gold nanoparticles Rajagopal Ramesh – Pathology and Stephenson Cancer Center Nanoparticles for gene and drug delivery for cancer treatment and exosomes for cancer therapy

Detamore Research Group Nanoparticles for tissue engineering: Hydrogel precursor solutions Tissue matrix – for example, cartilage particles

Harrison Research Group Single-walled carbon nanotubes for cancer therapy: Modes of heating: Near-infrared light Radiofrequency field Bladder cancer Breast cancer Melanoma Eye cancer Brain cancer Prostate cancer Gold nanoparticles for imaging:

Sikavitsas Research Group Nano- and micro-scale materials for tissue engineering: Orthopedic tissue engineering, including for tendons and bones Heparin functionalized PLLA fiber Polylactic acid scaffolds

Mao Research Group Phage nanomedicine applications: Gene/drug delivery Vaccines Tissue regeneration Directing the fate of stem cells Templating materials Self assembly

Mukherjee Research Group Gold nanoparticles for cancer therapy: Inhibition of growth and metastasis Modulation of trafficking and mechanism of antibody-induced receptor endocytosis Effect of nanoparticle surface charge at the plasma membrane

Y Ramesh Research Group Multifunctional nanoparticles for tumor-targeted delivery and imaging: Lipids Polymers Gold Applications for lung, breast, ovarian, and melanoma Exosomes as drug delivery vehicles for cancer therapy (“nanosomes”) Y Targeting Ligand Gene therapeutic Chemodrug Imaging agent Nanosomes