Robert C. Gorman, MDa(by invitation), Nicholas P

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Presentation transcript:

Surface-bound heparin fails to reduce thrombin formation during clinical cardiopulmonary bypass Robert C. Gorman, MDa(by invitation), Nicholas P. Ziats, PhDc (by invitation), A.Koneti Rao, MDb (by invitation), Nicolas Gikakis, BSa (by invitation), Ling Sun, MDb (by invitation), Mohammed M.H. Khan, MDb (by invitation), Nina Stenach, CCPa (by invitation), Suneeti Sapatnekar, MDc (by invitation), Vibhuti Chouhan, PhDb (by invitation), Joseph H. Gorman, MD (by invitation), Stefan Niewiarowski, MD, PhDb (by invitation), Robert W. Colman, MDb (by invitation), James M. Anderson, MD, PhDc (by invitation), L.Henry Edmunds, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 111, Issue 1, Pages 1-12 (January 1996) DOI: 10.1016/S0022-5223(96)70395-1 Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Platelet counts depicted as percentage of platelet count obtained before heparin at each time interval for each group. Means ± standard error. Diamonds indicate control group; squares indicate group in which coated circuits were used. See Table III for significant differences within and between groups. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 1-12DOI: (10.1016/S0022-5223(96)70395-1) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Plasma prothrombin fragment F1.2 at each time interval. Means ± standard error. Diamonds indicate control group; squares indicate group in which coated circuits were used. There were no significant differences between groups. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 1-12DOI: (10.1016/S0022-5223(96)70395-1) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 Plasma thrombin-antithrombin complex (TAT) at each time interval. Means ± standard error. Diamonds indicate control group; squares indicate group in which coated circuits were used. There were no significant differences between groups. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 1-12DOI: (10.1016/S0022-5223(96)70395-1) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 RIA for detection of adsorbed proteins on surfaces of arterial and venous tubing (n = 24). Data are expressed as counts per minute x 103 ± standard error of the mean of secondary 125I- labeled goat antirabbit immunoglobulin G binding to primary antibodies (rabbit antihuman immunoglobulin G) to antithrombin (AT), fibrinogen (FB), factor XII (XII), von Willebrand factor (vWF), or PBS control (CON). *p < 0.05 by Student's unpaired t statistic between groups. The Journal of Thoracic and Cardiovascular Surgery 1996 111, 1-12DOI: (10.1016/S0022-5223(96)70395-1) Copyright © 1996 Mosby, Inc. Terms and Conditions