Department of Anaesthesia and Intensive Care

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Presentation transcript:

Department of Anaesthesia and Intensive Care 34th SSAI Conference, Malmö 2017 Cooling in Sepsis Should fever be treated in ICU patients with infection or sepsis? Morten H. Bestle, MD, PhD, EDIC, Ass. Professor Nordsjællands Hospital, Hillerød, University of Copenhagen, Denmark morten.bestle@regionh.dk

Overall Conclusions 1 Fever in infected patients in the ICU is associated with a lower mortality and shorter hospital stays. In infected ICU patients, antipyretic therapy seems to be safe, but does not reduce mortality or length of stay. In septic shock, antipyretic therapy by (external cooling to normothermia) show improved hemodynamics and reduced early mortality .

Overall Conclusions 2 Mild induced hypothermia (MIH): Has multiple effects in septic shock. Animal studies of MIH for 24-72 hours generally show improved organ function and survival. Functional coagulation seem to be improved. It remains unclear whether MIH can improve the prognosis in septic shock. The CASS study will bring clarity to this.