Transcatheter interatrial shunt device (IASD)

Slides:

Advertisements

Similar presentations

Congestive Heart Failure

Advertisements

 Heart failure is a complex clinical syndrome Can result from:  structural or functional cardiac disorder  impairs the ability of the ventricle to.

Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiography substudy.

Structure and Function

1 Heart Failure William Chavey, MD, MS Associate Professor Department of Family Medicine University of Michigan.

Cvs module phase II MBBS CARDIAC CYCLE PHYSIOLOGY CARDIOVASCULAR MODULE PHASE II

Physical Education Studies

1 Cardiac Pathophysiology Part B. 2 Heart Failure The heart as a pump is insufficient to meet the metabolic requirements of tissues. Can be due to: –

Heart Failure Whistle Stop Talks No 1 HFrEF and HFpEF Definitions for Diagnosis Susie Bowell BA Hons, RGN Heart Failure Specialist Nurse.

HEART PHYSIOLOGY & CONDUCTION SYSTEM

JONATHAN MANT, MD; ABDALLAH AL-MOHAMMAD, MD; SHARON SWAIN, BA, PHD; AND PHILIPPE LARAMEE,DC,MSC, FOR THE GUIDELINE DEVELOPMENT GROUP CHRIS FONTIMAYOR MS-III.

Blood Pressure Is measured in arteries where it is highest Is measured in arteries where it is highest Pressure decreases with distance from heart Pressure.

What you do! Copy the text with a white background. Those with a pink background are for information only, and notes on these will be found in your monograph.

Target Study Cardiac resynchronization therapy (CRT) is an established treatment for advanced heart failure symptoms, impaired LV systolic function, and.

Frank-Starling Mechanism

C ARDIAC C YCLE. E ARLY DIASTOLE Pressure in ventricles is low. Pressure difference causes A-V valves to open and the ventricles to fill. 70% of returning.

EKG Ventricular Pressure Aortic Pressure Ventricular Volume P Mm Hg ml A The P wave denotes atrial depolarization.

Learning Objectives... To understand the stages of the cardiac cycle.

REVIEW: LABELED HEART DIAGRAM

Systolic Versus Diastolic Failure. Forms of Heart Failure Sytolic Failure Inability of the ventricle to contract normally and expel sufficient blood Inadequate.

The Cardiac Cycle. The repeating pattern of contraction (systole) and relaxation (diastole) of the heart The repeating pattern of contraction (systole)

Cardiovascular Physiology

Left ventricle Michel Slama Amiens France. LV ventricle Ejection fraction Cardiac output Left ventricular filling pressure.

Cardiac Cycle Dr. Wasif Haq. Introduction Cardiac events that occur from beginning of one heartbeat to the beginning of the next. Inversely proportional.

Blood Pressure Normal BP varies by age, but is approximately 120 mm Hg systolic over 80 mmHg diastolic in a healthy young adult ( in females, the pressures.

The Cardiac Cycle.

The cardiovascular system in action 1/Cardiac function and cardiac output 2/ Cardiac cycle.

Embargoed Until 3:45 p.m. ET, Sunday, Nov. 8, 2015

The cardiac cycle Ventricular filling the diastole refers to the period of the cardiac cycle during which the ventricles are filling with blood the systole.

Cardiac Cycle  Refers to pattern of ;  Systole (contraction)  Diastole (relaxation)  Shown by the heart in one complete cycle  On average this 1.

Events of the Cardiac Cycle Why did the blood flow across the valve? Desire - it wanted to Ability - it could do it Movement = Desire X Ability Flow.

BASIC INTRODUCTION OF ANATOMY OF HEART

Cardiac Cycle By Dr. Khaled Ibrahim Khalil By Objectives: By the end of this lecture, you should : By the end of this lecture, you should :  Describe.

1. LECTURE – 3 DR. ZAHOOR ALI SHAIKH 2 CARDIAC CYCLE  Cardiac events occurring during one beat (systole & diastole) are repeated during the next beat.

Cardiac Cycle- 1 Mechanical events, Volume & Pressure changes in cardiac chambers & the great vessels during the cardiac cycle.

Date of download: 11/13/2016 Copyright © The American College of Cardiology. All rights reserved. From: The Reality of Heart Failure in Latin America J.

Chronic heart failure By Vishal Patel GPVTS1.

Fig ACCF/AHA Guideline for the management of heart failure

Cardiac Cycle and Sounds

David M Kaye MD, PhD on behalf of the REDUCE LAP HF Investigators

Heart Failure With Preserved Left Ventricular Function: Diagnostic and Therapeutic Challenges in Patients With Diastolic Heart Failure Michael N. Young,

DIASTOLIC DYSFUNCTION and DIASTOLIC HEART FAILURE

AMERICAN HEART ASSOCIATION SCIENTIFIC SESSIONS 2017

AMERICAN HEART ASSOCIATION SCIENTIFIC SESSIONS 2017

Treatment of Heart Failure With Preserved Ejection Fraction: Have We Been Pursuing the Wrong Paradigm? Gerard O. Oghlakian, MD, Ilke Sipahi, MD, James.

AMERICAN HEART ASSOCIATION SCIENTIFIC SESSIONS 2017

The Electrocardiogram

Diastolic Heart Failure

Tetsuro Tsujimoto, Hiroshi Kajio International Journal of Cardiology

Textbook / WB pages Textbook: p , p , p , p WB , , ,

Contents The Anatomy of the Heart The Cardiac Cycle: Diagrams 1-14

The Circulatory System

Mirnela Byku, and Douglas L. Mann BTS 2016;1:95-106

Tetsuro Tsujimoto, Hiroshi Kajio International Journal of Cardiology

Initial Clinical Experience With the Symphony Heart Assist System

Use of continuous flow ventricular assist devices in patients with heart failure and a normal ejection fraction: A computer-simulation study Francesco.

Treatment of Heart Failure With Preserved Ejection Fraction: Have We Been Pursuing the Wrong Paradigm? Gerard O. Oghlakian, MD, Ilke Sipahi, MD, James.

Training Effects Amina & Drexler .

CHAMPION Trial design: Patients with recent hospitalization for heart failure were implanted with a pulmonary artery pressure monitor and randomized so.

Cardiovascular system- L3

Romain Gallet et al. BTS 2016;1:14-28

CARDIC CYCLE Dr. Haseeb Sattar.

The cardiac cycle.

Figure 3. Survival rates according to renal dysfunction

Khalid AlHabib Professor of Cardiac Sciences Cardiology Consultant

Rick A. Nishimura et al. JACC 2014;63:e57-e185

Algorithm for haemodynamic evaluation in the elderly.

Relationship between 6-month all-cause mortality and the three types of heart failure adjusted for age ≥75 years, peripheral edema at admission, systolic.

Presentation transcript:

Transcatheter interatrial shunt device (IASD) Lancet. 2016 Mar 26 A transcatheter intracardiac shunt device for heart failure with preserved ejection fraction (REDUCE LAP-HF): a multicentre, open-label, single-arm, phase 1 trial. Hasenfuß G1, Hayward C2, Burkhoff D3, Silvestry FE4, McKenzie S5, Gustafsson F6, Malek F7, Van der Heyden J8, Lang I9, Petrie MC10, Cleland JG11, Leon M12, Kaye DM13; REDUCE LAP-HF study investigators.

Heart failure: left ventricular systolic dysfunction (impairment in ability of the heart to pump sufficient amounts of blood into the circulation during systole) heart failure with preserved left ventricular ejection fraction (HFPEF) or “diastolic” heart failure (patients with normal left ventricular systolic function in whom higher filling pressures are needed to obtain a normal end‐diastolic volume of the left ventricle)1

Consequences: Exercise inevitably produce an abrupt rise in pulmonary and left atrial pressure, the main driver of dyspnoea in patients with heart failure with preserved ejection fraction.3

Heart failure with preserved ejection fraction (HFPEF) is a common, globally recognised, form of heart failure for which no treatment has yet been shown to improve symptoms or prognosis.2

Targets: patients older than 40 years of age with symptoms of HFPEF despite pharmacological therapy, left ventricular ejection fraction higher than 40%, and a raised pulmonary capillary wedge pressure at rest (>15 mm Hg) or during exercise (>25 mm Hg)2

Results: In this open-label study of a novel transcatheter interatrial shunt device, which was developed for the management of patients with HFPEF, we recorded reductions in left atrial pressure during exercise with improvements in functional capacity and quality of life 6 months after implantation.2

References: 1. https://www.ncbi.nlm.nih.gov/pubmed/17699180 2.https://www.ncbi.nlm.nih.gov/pubmed/?term=A+transcatheter+intracardiac+shunt+device+for+heart+failure+with+preserved+ejection+fraction+(REDUCE+LAP-HF)%3A+a+multicentre%2C+open-label%2C+single-arm%2C+phase+1+trial 3. https://www.ncbi.nlm.nih.gov/pubmed/27025419 Images: http://osuwmc.multimedianewsroom.tv/story.php?id=1130&enter http://corviamedical.com/treatment/