Medical Immunology

microorganism attack us be able to inside us A fight a body keep preventing the microorganisms from entry into the body and using us as host

immune system helping us against the microorganisms The primary function Immune defense

The first lecture a picture of how the immune system works

Adaptive immune system Innate immune system Adaptive immune system mechanical barrier unknown cell dendritic cell IL-4 IL-4 IL-5 naïve T cell helper T cell 2, Th2 IL-12 defensin helper T cell 1, Th1 cytotoxic T cell Interferon γ IL-2 macrophage cilia kill low pH

Two types of immune system Innate immune system Adaptive immune system T cells mediated cellular immune response B cells mediated humoral immune response

Innate and adaptive immune system Act in cooperative and interdependent ways Discuss the collaboration of these two forms of immune system. The innate immune system initiates the adaptive immune system The adaptive immune system enhances the activity in the innate immune system

Subsequent lectures immune organs Immune molecules Immune cells MHC, immunoglobulin, complement system, etc. Immune cells Macrophage, dendritic cell, T cell, B cell, etc Innate immune response Adaptive immune response

The immune system is a “Two-Edged Sword” Protection (protect the host from infectious diseases) Damage to the host Inappropriate reaction to “self”: autoimmune disease Ineffective immune response: immunodeficiency Overreactive immune response: hypersensitivity (clinical immunology)

Study question The immune response includes ( ) and ( ). A: innate immune response and adaptive immune response Adaptive immune response includes ( ) and ( ). A: cellular immune response and humoral immune response The cellular immune response is mediated by ( ) cells and the humoral immune response is mediated by ( ) cells. A: T cells and B cells

Study question Innate and adaptive immunity act in cooperative and interdependent ways to protect the host. Discuss the collaboration of these two forms of immunity.