Rosalyn Franklin “Dark Lady of Science”

Early Interest in Nucleic Acids 1939: 19-year-old student at Newnham College Studying chemistry Speculative sketch of nucleic acid “Geometrical basis for inheritance?”

Work with Coal Thesis was based on the holes in coal 1945: Received her PhD from Cambridge in physical chemistry Research had important industrial applications

X-Ray Diffraction One of the most capable practioners of the field Helped refine the technology 1951 moved to King’s College to do x-ray diffraction work

King’s College JT Randall asked her to work on the structure of DNA Believed x-ray work exclusively to herself Wilkins thought he was supposed to work with her Wilkins’ mentality Unhappy working atmosphere

Rosalyn’s Contributions Corrected Watson and Crick on their original model Her data gave full dimensions of the unit cell, its length, width and angles Provided the basic scientific evidence for the structure of the nucleic acid, DNA Phosphate groups lie on the outside of the molecule DNA chain has a helical conformation

Work Unrecognized 1952 Franklin had a full report written for the MRC 1962 Watson, Crick and Wilkins received the Nobel Prize Franklin did not, died 1958 Franklin’s memory was honored in the spring of 2000 with the opening of the Franklin-Wilkins Hall at King’s College

References Anonymous. Rosalyn Franklin. http://www2.carthage.edu/~pfaffle/hgp/Franklin.html Accessed 20 June 2005. Franklin, S. My aunt, the DNA pioneer. 24 April 2003. http://news.bbc.co.uk/1/ni/sci/tech/2895681.stm Accessed 20 June 2005.