Journal of Allergy and Clinical Immunology

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Presentation transcript:

Journal of Allergy and Clinical Immunology Early-life home environment and risk of asthma among inner-city children George T. O'Connor, MD, MS, Susan V. Lynch, PhD, Gordon R. Bloomberg, MD, Meyer Kattan, MD, Robert A. Wood, MD, Peter J. Gergen, MD, MPH, Katy F. Jaffee, MS, Agustin Calatroni, MS, Leonard B. Bacharier, MD, Avrahman Beigelman, MD, Megan T. Sandel, MD, MPH, Christine C. Johnson, PhD, Ali Faruqi, MS, Clark Santee, BS, Kei E. Fujimura, PhD, Douglas Fadrosh, MS, Homer Boushey, MD, Cynthia M. Visness, PhD, James E. Gern, MD Journal of Allergy and Clinical Immunology DOI: 10.1016/j.jaci.2017.06.040 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Allergen exposures and asthma relationships between exposure to specific allergens and asthma. The probability of asthma at age 7 years was determined by using logistic regression according to the sum of exposure tertiles (cockroach, mouse, cat, and dog). A, Sum of the exposures in the first year of life. B, Same as Fig 1, A, stratified by aeroallergen sensitization at age 3 years (pink = sensitive, blue = not sensitive). C, Cumulative sum of exposures across years 1, 2, and 3. D, Same as Fig 1, C, stratified by aeroallergen sensitization at age 3 years. P values are from a logistic regression model testing a relationship between exposure levels and asthma and stratified by sensitization in Fig 1, B and D. Journal of Allergy and Clinical Immunology DOI: (10.1016/j.jaci.2017.06.040) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Classified bacterial taxa in house dust at 3 months of age in relation to simultaneous dust allergen concentrations and to asthma status at age 7 years. The 356 classified bacterial taxa (taxa classified as “mitochondria” or unclassified at the phylum level were omitted from this figure) that differed (FDR < 0.05) between the homes of asthmatic and nonasthmatic subjects are shown as bars, with color indicating whether the taxon was more abundant in the homes of asthmatic (red) or nonasthmatic (blue) subjects and bar height indicating the magnitude of between-group relative abundance delta. Bacterial taxa with abundance that was correlated with allergen levels are indicated by circles above the bars, with color indicating the allergen and solid or open circles indicating positive or negative correlation, respectively. Journal of Allergy and Clinical Immunology DOI: (10.1016/j.jaci.2017.06.040) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Journal of Allergy and Clinical Immunology DOI: (10.1016/j.jaci.2017.06.040) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Journal of Allergy and Clinical Immunology DOI: (10.1016/j.jaci.2017.06.040) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Journal of Allergy and Clinical Immunology DOI: (10.1016/j.jaci.2017.06.040) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Journal of Allergy and Clinical Immunology DOI: (10.1016/j.jaci.2017.06.040) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions