Eric Niederhoffer SIU-SOM

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Presentation transcript:

Eric Niederhoffer SIU-SOM 5/9/2018 Neurotransmitters PLP (vit B6) deCO2ase Glutamate g-Aminobutyrate Dopamine Norepinephrine Epinephrine PLP (vit B6) deCO2ase Amino Acid Precursors Tyrosine PLP (vit B6) deCO2ase Tryptophan Serotonin PLP: pyridoxal phosphate deCO2ase: decarboxylase Eric Niederhoffer SIU-SOM

Pathway Catecholamines Tyrosine DOPA Dopamine Epinephrine 5/9/2018 Pathway Catecholamines Tyr OHase THBP, O2 PLP (vit B6) AAA deCO2ase Tyrosine DOPA Dopamine DbOHase Vit C, O2 Epinephrine PNMT SAM SAHC Norepinephrine THBP: tetrahydrobiopterin TyrOHAse: tyrosine hydroxylase, Fe-dependent DOPA: dihydroxyphenylalanine PLP: pyridoxal phosphate AAA deCO2ase: aromatic amino acid decarboxylase DbOHase: dopamine b-hydroxylase, Cu-dependent Vit C: vitamin C, ascorbic acid PNMT: phenylethanolamine-N-methyltransferase (the degradation enzyme is catechol-O-methyltransferase, acts on norepinephrine and epinephrine) SAM: S-adenosylmethionine SAHC: S-adenosylhomocysteine TrpOHase: tryptophan hydroxylase, Fe-dependent 5HTP: 5-hydroxytryptophan 5-HT: 5-hydroxytryptamine (serotonin) Trp OHase O2 THBP, PLP (vit B6) AAA deCO2ase Tryptophan 5HTP Serotonin (5-HT)

5/9/2018 Review Questions How are neurotransmitters synthesized (substrates, enzymes, coenzymes, cofactors)?