Per2 Bmal1 Per3 Cry2 Cry1 Clock Ror CSNK1 Per1 Rev-erb 0.05 0.1 0.15

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Per2 Bmal1 Per3 Cry2 Cry1 Clock Ror CSNK1 Per1 Rev-erb 0.05 0.1 0.15 0.2 0.25 0.3 0.35 A B D C Supplemental Figure 3. Cross-correlation analyses of clock gene expression in human peripheral blood leukocytes challenged with endotoxin or saline at 09:00 h or 21:00 h. The gene expression data for each subject was cross-correlated across all studied genes within a subject. The cross-correlation data were normalized to one, where one represents a perfect correlation between gene responses. The correlation matrices for (A) placebo day and night subjects (09:00 h plus 21:00 h saline infusion time; n=3), (B) endotoxin day subjects (09:00 h infusion; n=4), (C) endotoxin night subjects (21:00 h infusion; n=3), (D) endotoxin day and night subjects (09:00 h plus 21:00 h endotoxin infusion time; n=7), were clustered into a tree form.