Volume 36, Issue 3, Pages (March 2012)

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Volume 36, Issue 3, Pages 293-298 (March 2012) Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features Jaqueline Carvalho de Oliveira, Carlos Alberto Scrideli, María Sol Brassesco, Andressa Gois Morales, Julia Alejandra Pezuk, Rosane de Paula Queiroz, José Andres Yunes, Silvia Regina Brandalise, Luiz Gonzaga Tone Leukemia Research Volume 36, Issue 3, Pages 293-298 (March 2012) DOI: 10.1016/j.leukres.2011.10.005 Copyright © 2011 Elsevier Ltd Terms and Conditions

Fig. 1 Relative expression levels of miRNAs in ALL patients stratified according to biological and clinical features. (A) miR-196b expression in patients positive (left) or negative (right) for the presence of T-cell phenotype (P=0.01). (B) MiR-100 expression in ALL patients with less than 50,000/mm3 white blood cells (WBC) (left) or more than 50,000/mm3 WBC at diagnosis (P=0.01). (C) miR-100 expression in patients negative (left) or positive (right) for the presence of 12;21 translocation (P=0.04). (D) MiR-100 expression in patients negative (left) or positive (right) for the presence of hyperdiploidy (P=0.04). Mann–Whitney test. Leukemia Research 2012 36, 293-298DOI: (10.1016/j.leukres.2011.10.005) Copyright © 2011 Elsevier Ltd Terms and Conditions

Fig. 2 Relative expression levels of miRNAs in ALL patients stratified according to the presence of t(4;11). (A) MiR-128a expression in patients positive (left) or negative (right) for the presence of t(4;11) (P=0.03). (B) MiR-181b expression in patients positive (left) or negative (right) for the presence of t(4;11) (P=0.02). Mann–Whitney test. Leukemia Research 2012 36, 293-298DOI: (10.1016/j.leukres.2011.10.005) Copyright © 2011 Elsevier Ltd Terms and Conditions

Fig. 3 Relative expression levels of miRNAs in ALL patients stratified according to treatment parameters. (A) miR-125a-5p expression in patients with bone marrow classified as M1 (left) or M2/M3 (right) analyzed on day 28 (P=0.02). (B) Let-7e expression in patients with bone marrow classified as M1 (left) or M2/M3 (right) analyzed on day 28 (P=0.04). (C) Let-7e expression in patients with negative minimal residual disease (left) or positive analyzed on day 14 (P=0.02). Mann–Whitney test. Leukemia Research 2012 36, 293-298DOI: (10.1016/j.leukres.2011.10.005) Copyright © 2011 Elsevier Ltd Terms and Conditions