Figure 1. Dose modification scheme for the second cycle of capecitabine treatment. From: Adjuvant capecitabine chemotherapy using a tailored-dose strategy.

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Figure 1. Dose modification scheme for the second cycle of capecitabine treatment. From: Adjuvant capecitabine chemotherapy using a tailored-dose strategy in elderly patients with colon cancer Ann Oncol. 2010;23(4):911-918. doi:10.1093/annonc/mdr329 Ann Oncol | © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com

Figure 2. Dose modification diagram in all enrolled patients (N = 82). From: Adjuvant capecitabine chemotherapy using a tailored-dose strategy in elderly patients with colon cancer Ann Oncol. 2010;23(4):911-918. doi:10.1093/annonc/mdr329 Ann Oncol | © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com

Figure 3. The change in dose intensity during capecitabine chemotherapy (mean and standard error, mg/m<sup>2</sup>/day). From: Adjuvant capecitabine chemotherapy using a tailored-dose strategy in elderly patients with colon cancer Ann Oncol. 2010;23(4):911-918. doi:10.1093/annonc/mdr329 Ann Oncol | © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com

Figure 4. Kaplan–Meier curves of disease-free survival (A), recurrence-free survival (B), and overall survival (C). From: Adjuvant capecitabine chemotherapy using a tailored-dose strategy in elderly patients with colon cancer Ann Oncol. 2010;23(4):911-918. doi:10.1093/annonc/mdr329 Ann Oncol | © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com

Figure 5. The mean scores (circle) and standard deviation (bar) of scales and items of the QLQ-C30 just before the adjuvant chemotherapy (N = 57). One global scale (QL) and five functional scales, including physical functioning (PF), role functioning (RF), emotional functioning (EF), cognitive functioning (CF), and social functioning (SF), are shown on the left side; a higher score reflects a better level of functioning. Nine symptom scales, including fatigue (FA), nausea and vomiting (NV), pain (PA), dyspnea (DY), sleep disturbance (SL), appetite loss (AP), constipation (CO), diarrhea (DI), and financial difficulties (FI), are shown on the right side; a higher score represents a worse level of symptom. From: Adjuvant capecitabine chemotherapy using a tailored-dose strategy in elderly patients with colon cancer Ann Oncol. 2010;23(4):911-918. doi:10.1093/annonc/mdr329 Ann Oncol | © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com

Figure 6. (A) The changes of quality of life (QoL) scores in five functional and one global scales and (B) the changes of QoL scores in nine symptom scales. From: Adjuvant capecitabine chemotherapy using a tailored-dose strategy in elderly patients with colon cancer Ann Oncol. 2010;23(4):911-918. doi:10.1093/annonc/mdr329 Ann Oncol | © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com