Konzern Group Limited

Company Overview CMC (China Medicine Corporation) registered in Nevada, USA, is a comprehensive enterprise with a research and development centre, manufacturing facilities and well established sales network, engages in the production and distribution of prescription and over the counter ("OTC") drugs, traditional Chinese medicine products, herbs and dietary-supplements, medical devices, and medical formulations in China. Konzern Group Limited (Guangzhou, China) is a wholly-owned subsidiary of CMC. Guangzhou Co-win Bioengineering Co., Ltd ("Co-Win") is a high-tech enterprise which was jointly founded in 2006 by Jinan University and Konzern Group Ltd. 25 million Chinese Yuan was initially invested. Co-Win focuses on the industrialization of high-tech projects and is currently advancing the R & D and production of Aflatoxin B1-detoxifizyme and its related products, a national "863" high-tech project.

Contaminated cottonseed(a), corn(b), and rice(c) Biotech Innovation Aflatoxin-detoxifizyme (ADTZ) What is AFT? A kind of mycotoxin produced by Aspergillus flavus and Aspergillus parasiticus Speare. Including Aflatoxin B1,B2,G1,G2,M1 and M2 etc, among which AFB1 is the most toxic. Aspergillus flavus prefer warm and moist conditions to grow and produce toxins; most feed and food could be contaminated, such as peanut, corn, rice and milk. Aspergillus flavus Structure of AFB1 a b c Contaminated cottonseed(a), corn(b), and rice(c)

AFT Biotech Innovation death AFT is very toxic AFT has been classified as carcinogen of Group A by IARC, could cause human gastric carcinoma, liver cancer and lung cancer etc. Toxicity of AFT is 10 times of hydrocyanic acid and 68 times of arsenic. 0.294 mg/kg AFB1 could cause susceptive animals die of acute toxicity. Ways to harm human beings AFT food contamination feed contamination human Birds and beasts food chain Serious poisoning Light poisoning Toxin accumulation death lose weight, get sick tumor

Biotech Innovation Aflatoxin-detoxifizyme (ADTZ)

Biotech Innovation A New Fungi-found Enzyme: Aflatoxin B1-detoxifizyme (ADTZ) Protein extracted from a kind of edible fungi. Under mild conditions, ADTZ could interact with AFB1 to break the toxic structure bifuran and function as antidote against AFT. First discovered and isolated in international wide, was proved to be a new enzyme. An innovative, China-source discovery. Independent Intellectual Property Rights.（ Patents were granted to aflatoxin B1-detoxifizyme in 21 counties and regions, including the United States , European Union and Japan ） Authorized by Ministry of Agriculture of PRC, No. : (2010) 02

COWINZYM Feed additive——Aflatoxin B1-detoxifizyme Products COWINZYM Feed additive——Aflatoxin B1-detoxifizyme label 【Product Ingredients Analysis Certified Value】Activity of Aflatoxin B1-detoxifizyme≥6000 U/g; Crude Ash≤10%. 【Ingredients】Aflatoxin B1-detoxifizyme with furfur or other organic materials of same kind as carriers. 【Functions】 Reduce the residue of Aflatoxin B1 in the animal body （internal organs, blood and muscle）; Protect livers and increase immune performance; Reduce the subcutaneous hemorrhage caused by toxin and improve the quality of the carcass. 【Applicability】Feed for chicken and piglings. 【Direction for Use】6×106 ～ 3×107U /ton, mixed uniformly with ration.

of the other ingredients of the compound feed Products Cowinzym product inactive ingredient is organic, thus environmental friendly and safe Enzymatic detoxication without releasing any toxin and inducing any secondary pollution Complete absorption，the inactive ingredient is organic, thus can be digested and absorbed by animals. No adsorption of the other ingredients of the compound feed

Cowinzym- deintoxication mechanism targeting at the mycotoxin synergism Viruses Bacteria Trichothecenes Voitoxin T-2 Toxin Aflatoxin Ochracin Patulin Zearalenone Fumitremorgin protect liver Improve immunity COWINZYM By breaking down the aflatoxin and reducing the liver damages Cowinzym ensures the liver detoxifies toxicants and other toxin, thus the antitoxic and disease resistant effects are achieved.

Serum glutamic oxalacetic Physiological and biochemical effects on broilers Liver glutathione peroxidase Liver superoxide dismutase（SOD） Liver succinate dehydrogenase（SDH） Serum glutamic oxalacetic transaminase（GOT） Control group Challenge group Emzymatic challenge group Improve the antioxidant capacity of the liver and reduce the liver damage caused by the toxin

Increase average daily weight Improve the production performance of the AA broilers +4.8% Increase average daily weight gainand feed intake Average daily weight gain Control group Challenge group Emzymatic challenge group +3.25% Average daily feed intake

Protect the physiologic functions of the liver Physiological and biochemical effects on Piglets Protect the physiologic functions of the liver Liver catalase(CAT) Liver glutathione transferase(GR) Serum glutamic pyruvic transaminase(GPT) Serum glutamic oxalacetic transaminase(GOT) Control group Challenge group Emzymatic challenge group

Increase the feed intake Increase the body weight gain Improve the production performance of the piglets Body weight gain (kilo/pig) Control group Challenge Emzymatic challenge Feed intake (kilo/pig) Control group Challenge group Emzymatic challenge group Increase the feed intake Increase the body weight gain

Experiment conclusion Cowinzym can protect the animal liver and improve the animal immunocompetence . Cowinzym can improve the production performance. Using Cowinzym can bring significant economic benefits .

Aflatoxin-detoxifizyme (ADTZ) Quality Standards Items Specifications Formulation Farinose solid, yellowish to fawn Granularity(2.00 mm standard sieve) ≧99% Enzymatic activity of Aflatoxin B1- detoxifizyme ≧6000 U/g Crude ash ≦10% ﹡The permissible dose is based on the feed with the dry matter content of 88%.

International Trade Department International Cooperation Eleanor Luo International Trade Department Tel: 0086-20-87391718 Fax: 0086-20-87373030 E-mail: luolinling@konzern.com.cn eleanor.luo@cmc621.com Looking for Agents, Distributors and Cooperators all over the world