Xiaodong Zhou, Anne M. Smith, Mark L. Failla, Kristina E

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Estrogen status alters tissue distribution and metabolism of selenium in female rats Xiaodong Zhou, Anne M. Smith, Mark L. Failla, Kristina E. Hill, Zhongtang Yu Journal of Nutritional Biochemistry Volume 23, Issue 6, Pages 532-538 (June 2012) DOI: 10.1016/j.jnutbio.2011.02.008 Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 1 Body weights of female SD rats pre- and postsurgery. Surgery was performed at 7 weeks of age. Rats were randomized into three treatment groups: OVX (n=22); OVX+E2 (n=22) and Sham (n=24). Data are means±S.E.M.. ⁎Body weights of OVX+E2 group were significantly less than those of the other two groups (P<.05) at weeks 8–10. ⁎⁎At weeks 11 and 12, body weights of OVX>Sham >OVX+E2 (P<.05). Journal of Nutritional Biochemistry 2012 23, 532-538DOI: (10.1016/j.jnutbio.2011.02.008) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 2 Plasma concentration of 17β-estradiol (A) and ceruloplasmin activity (B) in treatment groups of female SD rats. The test groups include OVX with estrogen replacement (OVX+E2), OVX with placebo replacement (OVX) and sham operated with placebo replacement in the diestrus (D), proestrus (P), estrus (E) and metestrus (M) stages. Data are means±S.E.M. for six animals in each group. Bars with different letters differ significantly (P<.05). Journal of Nutritional Biochemistry 2012 23, 532-538DOI: (10.1016/j.jnutbio.2011.02.008) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 3 75Se activity in tissues at 1, 3, 6 and 24 h after gastric administration of 60 μCi 75SeO32− (OVX, closed circles; OVX+E2, open circles). (A) Gastrointestinal tract; (B) plasma; (C) RBC; (D) liver; (E) heart; (F) kidney; (G) thymus; (H), brain. Data are means±S.E.M. (n=4). Statistically significant differences (P<.05) between OVX group and OVX+E2 group are denoted by the presence of an asterisk (⁎). Within the same treatment (OVX or OVX+E2), means that do not share the same letter are significantly different at P<.05. Journal of Nutritional Biochemistry 2012 23, 532-538DOI: (10.1016/j.jnutbio.2011.02.008) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 4 75Se activity in plasma Sepp1 at 1, 3, 6 and 24 h after administration of 75SeO32− by gavage (OVX, closed circles; OVX+E2, open circles). Data are means±S.E.M. (n=4). Statistically significance (P<.05) differences between OVX group and OVX+E2 group at a specific time after dosing are denoted by presence of an asterisk (⁎). Within the same treatment (OVX or OVX+E2), means that do not share the same letter differ significantly (P<.05). Journal of Nutritional Biochemistry 2012 23, 532-538DOI: (10.1016/j.jnutbio.2011.02.008) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 5 Plasma Sepp1 concentration in treatment groups of female SD rats. The test groups include OVX with estrogen replacement (OVX+E2), OVX with placebo replacement (OVX) and sham operated with placebo replacement in the diestrus (D), proestrus (P), estrus (E) and metestrus (M) stages. Data are means±S.E.M. for six animals in each group. No differences in plasma Sepp1 concentrations were observed among groups (P>.05). Journal of Nutritional Biochemistry 2012 23, 532-538DOI: (10.1016/j.jnutbio.2011.02.008) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 6 Estrogen replacement in OVX rats increases levels of hepatic Sepp1 and GPx1 mRNA. Real-time RT-PCR was carried out with extracted RNA isolated from liver of OVX rats receiving estrogen replacement (OVX+E2) and OVX rats with placebo pellet (OVX). Data are normalized against GAPDH mRNA and presented as means±S.E.M. for six animals in each group. ⁎P<.05 between OVX and OVX+E2. Journal of Nutritional Biochemistry 2012 23, 532-538DOI: (10.1016/j.jnutbio.2011.02.008) Copyright © 2012 Elsevier Inc. Terms and Conditions