Polyphenols in brewed green tea inhibit prostate tumor xenograft growth by localizing to the tumor and decreasing oxidative stress and angiogenesis Susanne.

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Polyphenols in brewed green tea inhibit prostate tumor xenograft growth by localizing to the tumor and decreasing oxidative stress and angiogenesis Susanne M. Henning, Piwen Wang, Jonathan Said, Clara Magyar, Brandon Castor, Ngan Doan, Carmen Tosity, Aune Moro, Kun Gao, Luyi Li, David Heber Journal of Nutritional Biochemistry Volume 23, Issue 11, Pages 1537-1542 (November 2012) DOI: 10.1016/j.jnutbio.2011.10.007 Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 1 Body weight (A) and tumor volume (B) of SCID mice inoculated with LAPC4 prostate tumor cells and treated with brewed green tea or water (means±S.D., n=5, ⁎P≤.05). Journal of Nutritional Biochemistry 2012 23, 1537-1542DOI: (10.1016/j.jnutbio.2011.10.007) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 2 Concentration of total (free+conjugated) GTPs and their methyl metabolites in tumor tissue of mice treated with green tea (means±S.D., n=5, ⁎P≤.05). Journal of Nutritional Biochemistry 2012 23, 1537-1542DOI: (10.1016/j.jnutbio.2011.10.007) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 3 (A) Gene expression of DNMT1 and (B) protein expression of DNMT1 in tumor tissue of mice treated with tea or water determined by quantitative real-time PCR (means±S.D., n=5, ⁎P≤.05). Journal of Nutritional Biochemistry 2012 23, 1537-1542DOI: (10.1016/j.jnutbio.2011.10.007) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 4 Oxidative DNA damage (A) in xenograft LAPC4 tumor or normal prostate tissue in intact (I) or castrated (C) mice; significant difference between tumor and prostate in intact (♦) and castrated mice (⁎). (B) Oxidative damage in tumor tissue and (C) oxidative protein damage in tumor tissue of mice treated with green tea or water (means±S.D., n=5, ⁎P≤.05). Journal of Nutritional Biochemistry 2012 23, 1537-1542DOI: (10.1016/j.jnutbio.2011.10.007) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 5 Protein expression of (A) HIF-1α and (B) VEGF in tumor tissue of mice treated with green tea or water by Western blot and (C) microvessel density by immunohistochemistry (means±S.D., n=5, ⁎P≤.05). Journal of Nutritional Biochemistry 2012 23, 1537-1542DOI: (10.1016/j.jnutbio.2011.10.007) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 6 Macrophage presence in tumor tissue of mice treated with green tea (A) or water (B) by F4/80 immunohistochemistry staining (×50 magnification). Journal of Nutritional Biochemistry 2012 23, 1537-1542DOI: (10.1016/j.jnutbio.2011.10.007) Copyright © 2012 Elsevier Inc. Terms and Conditions