The effects of dietary fatty acids on the postprandial triglyceride-rich lipoprotein/apoB48 receptor axis in human monocyte/macrophage cells Lourdes.

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The effects of dietary fatty acids on the postprandial triglyceride-rich lipoprotein/apoB48 receptor axis in human monocyte/macrophage cells Lourdes M. Varela, Almudena Ortega-Gomez, Sergio Lopez, Rocio Abia, Francisco J.G. Muriana, Beatriz Bermudez Journal of Nutritional Biochemistry Volume 24, Issue 12, Pages 2031-2039 (December 2013) DOI: 10.1016/j.jnutbio.2013.07.004 Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 1 Effects of TRL-butter (red), TRL-HPSO (orange), TRL-ROO (green) and TRL-VEFO (blue) on ApoB48R mRNA levels in THP-1 monocytes (left panels) and THP-1-derived macrophages (right panels). In A and B, postprandial TRL was 50-μg triglycerides/ml for 12 h. In B and C, postprandial TRL was 50-μg triglycerides/ml for indicated times. In E and F, the MUFA oleic acid (18:1ω-9)-to-SFA palmitic acid (16:0) ratios were obtained from Table 2. Data are expressed as the means±S.D. of nine experiments. Superscripted letters (a–d) indicate a significant difference between postprandial TRL (P<.05). Journal of Nutritional Biochemistry 2013 24, 2031-2039DOI: (10.1016/j.jnutbio.2013.07.004) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 2 Effects of butter (red) and ROO (green) meals on ApoB48R mRNA levels and triglyceride accumulation in postprandial monocytes (A–C) and the effects of TRL-butter (red) and TRL-ROO (green) on ApoB48R mRNA levels and triglyceride accumulation in primary monocytes (D, E). In A–C, data are expressed as the means±S.D. of 12 volunteers. In D and E, postprandial TRL was 50-μg triglycerides/ml for 12 h, and data are expressed as the means±S.D. of nine experiments. Superscripted letters (a–c) indicate a significant difference between meals and postprandial TRL (P<.05). Journal of Nutritional Biochemistry 2013 24, 2031-2039DOI: (10.1016/j.jnutbio.2013.07.004) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 3 Effects of TRL-butter (red), TRL-HPSO (orange), TRL-ROO (green) and TRL-VEFO (blue) on ApoB48R mRNA levels (A, B) and lipid accumulation (A–H) in THP-1 monocytes (left panels) and THP-1-derived macrophages (right panels). In C–H, ApoB48R was silenced, the MUFA oleic acid (18:1ω-9)-to-SFA palmitic acid (16:0) ratios were obtained from Table 2, and lipid changes were obtained from Table 3. In all panels, postprandial TRL was 50-μg triglycerides/ml for 12 h. Data are expressed as the means±S.D. of nine experiments. Journal of Nutritional Biochemistry 2013 24, 2031-2039DOI: (10.1016/j.jnutbio.2013.07.004) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 4 Effects of TRL-butter (red) and TRL-ROO (green) on ApoB48R mRNA levels in THP-1 monocytes (left panels) and THP-1-derived macrophages (right panels) in the absence or presence of PPARα, PPARβ/δ and PPARγ agonists (A, B) or antagonists (C, D). In all panels, postprandial TRL was 50-μg triglycerides/ml for 12 h. Data are expressed as the means±S.D. of nine experiments. Superscripted letters (a–c) indicate a significant difference between treatments (P<.05). Journal of Nutritional Biochemistry 2013 24, 2031-2039DOI: (10.1016/j.jnutbio.2013.07.004) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 5 Effects of TRL-butter (red) and TRL-ROO (green) on ApoB48R mRNA levels in THP-1 monocytes (left panels) and THP-1-derived macrophages (right panels) in the absence or presence of RXRα agonist (A, B), antagonist or RXRα-siRNA (C, D), acyl-CoA synthetase or ACAT inhibitor (E, F). In all panels, postprandial TRL was 50-μg triglycerides/ml for 12 h. Data are expressed as the means±S.D. of nine experiments. Superscripted letters (a–d) indicate a significant difference between treatments (P<.05). Journal of Nutritional Biochemistry 2013 24, 2031-2039DOI: (10.1016/j.jnutbio.2013.07.004) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 6 The proposed model of postprandial TRL/ApoB48R axis regulation by dietary MUFA oleic acid and SFA palmitic acid in human monocyte/macrophage cells. Journal of Nutritional Biochemistry 2013 24, 2031-2039DOI: (10.1016/j.jnutbio.2013.07.004) Copyright © 2013 Elsevier Inc. Terms and Conditions