Part I: Liver function in oncology: biochemistry and beyond

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Part I: Liver function in oncology: biochemistry and beyond Kathryn M Field, MBBS Hons, Chris Dow, FRCPA, Dr Michael Michael, MBBS Hons The Lancet Oncology Volume 9, Issue 11, Pages 1092-1101 (November 2008) DOI: 10.1016/S1470-2045(08)70279-1 Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 1 Histology of healthy liver Portal tract contains bile duct, hepatic artery, and portal vein (upper right); central vein shown (lower left); and hepatocytes line sinusoids in centre of image. Cords and plates of hepatocytes are one-cell thick between sinusoids. Haematoxylin and eosin stain, ×200 magnification. The Lancet Oncology 2008 9, 1092-1101DOI: (10.1016/S1470-2045(08)70279-1) Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 2 Histopathological injury secondary to chemotherapy Macrovesicular and microvesicular steatosis, ×400 magnification (A, arrows) and sinusoidal dilatation, ×200 magnification (B, arrows) in patients given neoadjuvant FOLFOX (fluorouracil, leucovorin, and oxaliplatin) before liver resection for metastatic colorectal cancer. Cells in both panels stained with haematoxylin and eosin. The Lancet Oncology 2008 9, 1092-1101DOI: (10.1016/S1470-2045(08)70279-1) Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 3 Hepatic veno-occlusive disease after chemotherapy and abdominal radiotherapy (A) Fibrosis and near-obliteration of venule (arrow), with atrophy and congestion of hepatic parenchyma (haematoxylin and eosin stain, ×200 magnification). (B) Collagen of venule wall (arrow) and loose fibrosis has almost obliterated venule lumen (Masson trichrome stain, ×200 magnification). The Lancet Oncology 2008 9, 1092-1101DOI: (10.1016/S1470-2045(08)70279-1) Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 4 Assessment before chemotherapy: identification of patients at risk of hepatotoxicity The Lancet Oncology 2008 9, 1092-1101DOI: (10.1016/S1470-2045(08)70279-1) Copyright © 2008 Elsevier Ltd Terms and Conditions