Dietary nitrite induces nitrosation of the gastric mucosa: the protective action of the mucus and the modulatory effect of red wine Cassilda Pereira,

Slides:

Advertisements

Similar presentations

ABO-incompatible kidney transplantation Kota Takahashi, Kazuhide Saito Transplantation Reviews Volume 27, Issue 1, Pages 1-8 (January 2013) DOI: /j.trre

Advertisements

Mulberry fruit ameliorates Parkinson's-disease-related pathology by reducing α- synuclein and ubiquitin levels in a 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine/probenecid.

Metformin prevents glucotoxicity by alleviating oxidative and ER stress–induced CD36 expression in pancreatic beta cells Jun Sung Moon, Udayakumar Karunakaran,

Effects of biotin deficiency on pancreatic islet morphology, insulin sensitivity and glucose homeostasis Elena Larrieta, Maria Luisa Lazo de la Vega-Monroy,

Wild blueberry (Vaccinium angustifolium) consumption improves inflammatory status in the obese Zucker rat model of the metabolic syndrome Stefano Vendrame,

Anna Castell-Auví, Lídia Cedó, Victor Pallarès, M

(−)-Epicatechin reduces blood pressure increase in high-fructose-fed rats: effects on the determinants of nitric oxide bioavailability Maria C. Litterio,

Magnesium deficiency results in an increased formation of osteoclasts

Maternal taurine supplementation attenuates maternal fructose-induced metabolic and inflammatory dysregulation and partially reverses adverse metabolic.

The effects of dietary fatty acids on the postprandial triglyceride-rich lipoprotein/apoB48 receptor axis in human monocyte/macrophage cells Lourdes.

High-protein diets prevent steatosis and induce hepatic accumulation of monomethyl branched-chain fatty acids Sonia C. Garcia Caraballo, Tine M. Comhair,

Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome M. Miriam Jacome-Sosa, Faye.

You-Lin Tain, Kay L.H. Wu, Wei-Chia Lee, Steve Leu, Julie Y.H. Chan

Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis S. Silva, B. Sepodes,

Effect of excess iron on oxidative stress and gluconeogenesis through hepcidin during mitochondrial dysfunction Hyo Jung Lee, Joo Sun Choi, Hye Ja Lee,

Dietary flavonoid apigenin inhibits high glucose and tumor necrosis factor α-induced adhesion molecule expression in human endothelial cells Kazuo Yamagata,

Dietary apigenin regulates high glucose and hypoxic reoxygenation-induced reductions in apelin expression in human endothelial cells Kazuo Yamagata,

EGCG prevents PCB-126-induced endothelial cell inflammation via epigenetic modifications of NF-κB target genes in human endothelial cells Dandan Liu,

Chrysin restores PDGF-induced inhibition on protein tyrosine phosphatase and reduces PDGF signaling in cultured VSMCs Huey-Ming Lo, Min-Wen Wu, Shiow-Lin.

Different effects of catechin on angiogenesis and inflammation depending on VEGF levels Rita Negrão, Raquel Costa, Delfim Duarte, Tiago Taveira Gomes,

Primary vitamin D receptor target genes as biomarkers for the vitamin D3 status in the hematopoietic system Julia Wilfinger, Sabine Seuter, Tomi-Pekka.

Primary vitamin D receptor target genes as biomarkers for the vitamin D3 status in the hematopoietic system Julia Wilfinger, Sabine Seuter, Tomi-Pekka.

Maharshi Bhaswant, Hemant Poudyal, Lindsay Brown

Eicosapentaenoic acid regulates brown adipose tissue metabolism in high-fat-fed mice and in clonal brown adipocytes Mandana Pahlavani, Fitia Razafimanjato,

Volume 33, Pages (January 2017)

Mubeen Ahmad Ansari, Hafiz Mohammad Abdul, Gururaj Joshi, Wycliffe O

Effect of 2-year placebo-controlled immunotherapy on airway symptoms and medication in patients with birch pollen allergy Monica B. Arvidsson, MD, Olle.

Amany K. Elshorbagy, Chris Church, Maria Valdivia-Garcia, A

Amany K. Elshorbagy, Chris Church, Maria Valdivia-Garcia, A

Volume 21, Issue 2, Pages (June 2014)

Volume 199, Issue 1, Pages (January 2018)

L.E. Rhodes Journal of Investigative Dermatology

S. Picardi, M. F. Stevens, K. Hahnenkamp, M. E. Durieux, P. Lirk, M. W

Etienne Roux, Marko Marhl Biophysical Journal

Involvement of Oxidative Stress in Apoptosis Induced by a Mixture of Isothiazolinones in Normal Human Keratinocytes Anna Ettorre, Paolo Neri, Anna Di.

Volume 21, Issue 2, Pages (June 2014)

Donald Gardenier The Journal for Nurse Practitioners

An Unexpected Role: UVA-Induced Release of Nitric Oxide from Skin May Have Unexpected Health Benefits Gary M. Halliday, Scott N. Byrne Journal of Investigative.

Covalent inhibition of carboxylesterase-2 by sofosbuvir and its effect on the hydrolytic activation of tenofovir disoproxil Yuanjun Shen, Bingfang Yan

Cross-Linking of SPINK6 by Transglutaminases Protects from Epidermal Proteases Jan Fischer, Yulia Koblyakova, Ties Latendorf, Zhihong Wu, Ulf Meyer-Hoffert

Volume 20, Issue 5, Pages (May 1998)

A. Dinse, K.J. Fo¨hr, M. Georgieff, C. Beyer, A. Bulling, H.U. Weigt

Volume 118, Issue 2, Pages (February 2000)

Antibodies Elicited by Inactivated Propionibacterium acnes-Based Vaccines Exert Protective Immunity and Attenuate the IL-8 Production in Human Sebocytes:

Volume 89, Issue 5, Pages (May 1997)

Volume 74, Issue 5, Pages (May 1998)

Bach-Cuc Nguyen, Irene E. Kochevar

A Model of the Oscillatory Metabolism of Activated Neutrophils

Catherine J. Hunter, Isabelle G. De Plaen Pathophysiology

PARP Determines the Mode of Cell Death in Skin Fibroblasts, but not Keratinocytes, Exposed to Sulfur Mustard Dana Anderson, Betty Benton, Zhao-Qi Wang,

TaiHao Quan, TianYuan He, Sewon Kang, John J. Voorhees, Gary J

How Integration of Positive and Negative Regulatory Signals by a STAND Signaling Protein Depends on ATP Hydrolysis Emélie Marquenet, Evelyne Richet

Volume 42, Issue 6, Pages (June 2005)

Acute exercise induce endothelial nitric oxide synthase phosphorylation via Akt and AMP-activated protein kinase in aorta of rats: Role of reactive oxygen.

The DNA Damage Machinery and Homologous Recombination Pathway Act Consecutively to Protect Human Telomeres Ramiro E. Verdun, Jan Karlseder Cell Volume.

Skin Sensitization to p-Phenylenediamine: The Diverging Roles of Oxidation and N- Acetylation for Dendritic Cell Activation and the Immune Response Pierre.

Donald Gardenier The Journal for Nurse Practitioners

Michael C. Puljung, William N. Zagotta Biophysical Journal

Guillaume Bossis, Frauke Melchior Molecular Cell

Chien-Jung Lo, Mark C. Leake, Richard M. Berry Biophysical Journal

Nitric oxide and glomerulonephritis

Volume 94, Issue 9, Pages (May 2008)

Table of contents The Journal for Nurse Practitioners

Journal of Investigative Dermatology

Effects of pregabalin on the activity of glutamate transporter type 3

Nitric Oxide Appears to Be a Mediator of Solar-Simulated Ultraviolet Radiation-Induced Immunosuppression in Humans Johanna M. Kuchel, Ross St C. Barnetson,

Augmentation of Staphylococcal α-Toxin Signaling by the Epidermal Platelet-Activating Factor Receptor Jeffrey B. Travers, Donald Y.M. Leung, Christopher.

Spectral Responses of Melanin to Ultraviolet A Irradiation

Effects of FK506 in rat and human resistance arteries

Volume 97, Issue 7, Pages (October 2009)

Presentation transcript:

Dietary nitrite induces nitrosation of the gastric mucosa: the protective action of the mucus and the modulatory effect of red wine Cassilda Pereira, Rui M. Barbosa, João Laranjinha Journal of Nutritional Biochemistry Volume 26, Issue 5, Pages 476-483 (May 2015) DOI: 10.1016/j.jnutbio.2014.12.004 Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 1 Typical nitric oxide chemiluminescent signals obtained after duplicate injections (100μl) of nitrite standard solutions (from 50 nM to 10μM) into the reaction mixture. Inset: Standard calibration curve from the same experiment obtained by plotting the geometric mean±S.E.M. of the areas under curve (AUC) of individual peaks vs. nitrite concentration. Journal of Nutritional Biochemistry 2015 26, 476-483DOI: (10.1016/j.jnutbio.2014.12.004) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 2 Nitrosation of mucin by nitrite under simulated gastric conditions. The values are expressed as mean±S.E.M., n=2–3. Journal of Nutritional Biochemistry 2015 26, 476-483DOI: (10.1016/j.jnutbio.2014.12.004) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 3 Pattern of gastric mucus nitrosation upon nitrite exposure under simulated gastric conditions ex vivo in a whole stomach model (left) and the corresponding nitric oxide formation in vitro (right) in a similar medium. Values are mean±S.E.M. (n=3–7). Journal of Nutritional Biochemistry 2015 26, 476-483DOI: (10.1016/j.jnutbio.2014.12.004) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 4 Gastric mucus nitrosation pattern upon exposure to nitrite and red wine (RW) mixtures under simulated gastric conditions (left). Right, in vitro nitric oxide formation from acidic nitrite from the corresponding mixtures. Values are mean±S.E.M. (n=3–7), *P<.05. Journal of Nutritional Biochemistry 2015 26, 476-483DOI: (10.1016/j.jnutbio.2014.12.004) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 5 Pattern of gastric mucosa nitrosation upon nitrite exposure under simulated gastric conditions ex vivo in a whole stomach model (left) and the corresponding nitric oxide formation in vitro (right) in a similar medium. Values are mean±S.E.M. (n=3–4). Journal of Nutritional Biochemistry 2015 26, 476-483DOI: (10.1016/j.jnutbio.2014.12.004) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 6 Effect of red wine (RW) on the nitrosation pattern of gastric mucosa challenged with nitrite under simulated gastric conditions (left). Right, in vitro nitric oxide formation from acidic nitrite from the corresponding mixtures. Values are mean±S.E.M. (n=3), *P<.05. Journal of Nutritional Biochemistry 2015 26, 476-483DOI: (10.1016/j.jnutbio.2014.12.004) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 7 Effect of mucus gel removal on the nitrosation of the gastric mucosa exposed to nitrite (1mM). Mucus was removed by scrapping or by pre-incubation of the mucosa with 2 % N-acetyl-cysteine (NAC). Values are mean±S.E.M. (n=3), *P<.05, relative to control. Journal of Nutritional Biochemistry 2015 26, 476-483DOI: (10.1016/j.jnutbio.2014.12.004) Copyright © 2015 Elsevier Inc. Terms and Conditions