American Evaluation Association The International Cancer Research Partnership: A Global Collaboration Enabling Analyses of Sponsor-Funded Cancer Research Panel Session 2549 American Evaluation Association EVALUATION 2015 November 11, 2015

Kari Wojtanik and Lynne Davies Session Presenters Elizabeth Hsu Session Chair Miranda Kleijn Translational Research: Monitoring Trends in the International Cancer Portfolio Senaida Poole Prevention Research: Utilizing a Global Database to Identify and Act on Trends in Research Funding Kari Wojtanik and Lynne Davies Global Assessment of Funding Trends Across a Diverse Spectrum of Issues in Breast Cancer Research Samantha Finstad Assessment of the International Cancer Research Partnership Lung Cancer Portfolio

ICRP: adding value to cancer research ICRP’s mission is to add value to cancer research efforts internationally by fostering collaboration and strategic co-ordination between cancer research organizations. Mission www.icrpartnership.org ICRP Chair 2015-2017: Dr. Miranda Kleijn Vice-Chair: Dr. Katie McKenzie

History & milestones 2000 Cancer “CSO” classification tool developed by NCI & CDMRP 8 organizations invited to join 2003 First generation website launched 2010 Agreement to share full data between Partners 2011 New website launched to Partners, giving access to improved analytical tools 2012 Public launch of new ICRP site First international analysis of cancer research (2005-2008) published 2015 Data from 109 organizations included in the ICRP database Planned launch of 2nd International analysis of cancer research (2005+) Brief history & milestones

Who is involved? Coalition against Childhood Cancer & Cancer Institute NSW new in 2015

ICRP Coding and Database Participating organizations/agencies share high quality, coded data The ICRP database contains data on more than 76,000 grants from 109 organizations (> $6bn p.a.) and is expanding every month. We use this unique resource to ask: What are the gaps in cancer research? What are the trends in cancer research funding? What types of projects have been funded (e.g. clinical, research, training)? What research areas are being funded (CSO)? What types of cancer are being funded? What is the funding profile across different countries and organizations? How can we maximize our research efforts? How can we foster strategic collaborations between funding organizations? What we do – data No. of orgs correct as of 1 April 2014 https://www.icrpartnership.org/database.cfm

Common Scientific Outline (CSO) (ver 2) 1. Biology 1.1 Normal functioning 1.2 Chromosome alterations 1.3 Oncogenes and tumor suppressor genes 1.4 Progression and metastasis 1.5 Resources and infrastructure 2. Etiology 2.1 Exogenous factors 2.2 Endogenous factors 2.3 Interactions 2.4 Resources and infrastructure 3. Prevention 3.1 Behavior interventions 3.2 Dietary interventions 3.3 Chemoprevention 3.4 Vaccines 3.5 Complementary and alternative approaches 3.6 Resources and infrastructure 4. Early detection, diagnosis and prognosis 4.1 Development and discovery 4.2 Evaluation 4.3 Testing in clinical setting 4.4 Resources and infrastructure 5. Treatment 5.1 Localized - Development 5.2 Localized - Clinical 5.3 Systemic - Development 5.4 Systemic - Clinical 5.5 Localized + Systemic 5.6 Complementary and alternative approaches 5.7 Resources and infrastructure 6. Control, survivorship, outcome 6.1 Care and survivorship 6.2 Surveillance 6.3 Behavior 6.4 Health services 6.5 Education 6.6 End-of-life care 6.7 Ethics 6.9 Resources and infrastructure CSO v2 released in April 2015. Coding modified to adapt to evolution in science/research, and learned from strengths/weaknesses of version 1. Further details on this will be given in the prevention presentation. https://www.icrpartnership.org/CSO.cfm

Cancer Site Codes 47 cancer site codes 9 ‘roll up’ codes (e.g., urinary cancers, blood cancers) Coded with a “percent relevance” to the site; may sum to more than 100%

Enables structured searches of 1000s of awards Comprehensive search functionality Users can search by year, organization, city, country, CSO, cancer type, keyword, project type, PI Name….

ICRP: data at the touch of a button Lung cancer research by CSO code, internationally Oesophageal cancer research in the UK

Understanding the cancer research landscape ICRP publishes regular data reports 2005-2008 benchmark analysis of cancer research funding 2005-2012 trend analysis of international cancer research (publication due in 2015) ICRP data contributes to topic-specific reports led by ICRP or partner organizations Recent ICRP publications: Obesity & cancer (2014) Environmental influences on breast cancer (2014) Metastatic breast cancer (2014) How data helps – ICRP report (2005-2008 data), included in other reports too https://www.icrpartnership.org/publications.cfm

Enabling Cross-Funder Multinational Analyses All grants submitted to the ICRP database are classified by CSO “Type of research” Cancer site “Type of cancer” ICRP partners and staff are also developing new tools and methodologies to mine this dataset in more detail Cross-cutting analysis using keywords, boolean searches Extracting award data and adding meta-data through a combination of semi-automated and manual coding Investigating new tools in partnership with others to add value to the data Case studies presented today: Translational research: monitoring trends in the international cancer portfolio Prevention research: Utilizing a global database to identify and act on trends in research funding Global assessment of funding trends across a diverse spectrum of issues in breast cancer research Assessment of the International Cancer Research Partnership lung cancer portfolio