IMPLANTABLE DRUG DELIVERY SYSTEM SEMINAR ON Department of Pharmaceutics

DEFINITION Implants are object or material inserted or grafted into the body for therapeutic, diagnostic, or experimental purposes. Implants are also defined as sterile drug product made by compression, inching, or sintering. Implants consist of drug and rate-controlling excipients. EXAMPLE:- 1) Gliadel wafer implants. 2) Zoladex implants.

IDEAL PROPERTIES OF IMPLANTS 1) Environmentally stable. 2) Biostable. 3) Biocompatible. 4) Non toxic and non-carcinogenic. 5) Minimum surface area, smooth texture. 6) Easily removable. 7) Medicament released rate.

Mechanism of drug release from implantable system 1) Diffusion controlled. 2) chemically controlled. 3) swelling controlled. 4) osmotically controlled. 5) magnetic controlled.

implantable drug delivery system an introduction : Implantable drug delivery system an introduction Implantable drug delivery systems are placed completely under the skin — usually in a convenient but inconspicuous location. The patient is aware of only a small bump under the skin. designed to transmit drugs and fluids into the bloodstream without the repeated insertion of needles. well suited to the drug delivery requirements of insulin, steroids, chemotherapeutics, antibiotics, analgesics, total parenteral nutrition, and heparin.

Approaches to design implantable drug delivery systems Controlled drug delivery by diffusion process Polymer membrane permeation- controlled drug delivery Matrix diffusion-controlled drug delivery Microreservior partition-controlled drug delivery system Membrane matrix hybrid-type drug delivery system

b) Controlled drug delivery by activation process. Osmotic pressure Vapor pressure Magnetically Hydration Hydrolysis c) Controlled drug delivery by feed back regulated mechanism. Bioerosion Bioresponce

Controlled drug delivery by diffusion process   1) membrane permeation- controlled drug delivery. Non porous membrane. Micro porous membrane. Semi permeable membrane. drug encapsulated within a drug reservoir. drug release surface is covered by a rate limiting polymeric membrane.

Types of Implants Screw Implants (Left to Right: TPS screw, Ledermann screw, Branemark screw, ITI Bonefit screw)                                                                                                                                Cylinder Implants (Left to Right: IMZ, Integral, Frialit-1 step-cylinder, Frialit-2 step-cylinder)

Advantages: Disadvantages: Invasive Convenience Termination Compliance Potential for controlled release Improved drug delivery Flexibility Disadvantages:  Invasive Termination Danger of device failure  Limited to potent drugs Possibility of adverse reactions Commercial disadvantages

REFERENCES: MODERN PHARMACEUTICS Fourth Edition, Revised and Expanded edited by Gilbert S. Banker University of Iowa, Iowa City, Iowa Christopher, T. Rhodes University of Rhode, Island Kingston, Drug delivery to pulmonary system .(CHAPTER 14) PHARMACEUTICAL PARTICULATE CARRIERS THERAPEUTIC APPLICATIONS Alain Rolland Vol-61 Dekker Publications. (PAGE NO: 31-59) PHYSIOLOGICAL PHARMACEUTICALS BIOLOGICAL BARRIERS TO DRUG ABSORPTION By Clive g.Wilson and Neena Washington. CONTROLLED AND TARGETED DRUG DELIVERY ADVANCES AND CONCEPTS By S.P Vyas And R.P. Khar.