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The association between social jetlag, the metabolic syndrome and type 2 diabetes mellitus in the general population: the New Hoorn study Femke Rutters, PhD

Question?

Introduction Circadian rhythm Metabolism & Behavior Jetlag, shift work

Introduction Social jetlag

AIM To assess the association of social jetlag with the metabolic syndrome and type 2 diabetes mellitus, in a population-based cohort.

Materials and Methods New Hoorn Study Cohort

Materials and Methods Poisson and linear regression

Results Social j <1 h Social j 1-2h Social j >2h Number (n, %)   Social j <1 h Social j 1-2h Social j >2h Number (n, %) 971 497 117 Sex (men %) 46 47 59 Age (years) 64 ± 6 57 ± 5 Education level (low %) 6 3 2

Results Metabolic syndrome >61 y <61 y Crude Adjusted Social j 1-2h 1.13 (0.8; 1.6) 0.86 (0.6; 1.3) Social j > 2h 1.19 (1.3; 2.9) 0.39 (0.1; 1.5) 1.22 (0.8; 1.8) 1.04 (0.7; 1.6) 2.06 (1.3; 3.3) 0.58 (0.2; 2.2)

Results Pre-diabetes >61 y <61 y Crude Adjusted Social j 1-2h 1.35 (1.0; 1.8) 0.94 (0.7; 1.2) Social j > 2h 1.79 (1.3; 2.5) 0.58 (0.3; 1.3) 1.39 (1.0; 1.9) 0.89 (0.7; 1.2) 1.73 (1.2; 2.5) 0.54 (0.3; 1.2)

Discussion Social jetlag, 2x higher risk Younger population Jetlag, shift work

Discussion

Conclusion In our population-based cohort social jetlag was associated with a 2-fold increased risk of the metabolic syndrome and (pre-)diabetes mellitus, especially in younger participants. f.rutters@vumc.nl

Take home message

Conclusion In our population-based cohort social jetlag was associated with a 2-fold increased risk of the metabolic syndrome and (pre-)diabetes mellitus, especially in younger participants. f.rutters@vumc.nl