Projects, Papers and Plans

iPRD Academic Expertise Synthesis and Process Process Engineering Crystallisation/ Particle Science Manufacturability Catalysis

Projects Driving Down The Cost of Waste Derived Sugar - Completed BioPlastic Polymers Based On Aromatic Dicarboxylic Acids Derived from Lignin – On going ProPAT – Integrated Process Control – On-going Intensified by Design (IbD) Advanced Digital Design of Pharmaceutical Therapeutics (ADDOPT) IMI Chem21 - Completed ACS Green Chemistry Institute Roundtable – On-going Centre for Manufacturability Design –On-going Eclair. Combined continuous reactor and work up Intenso - process intensification of solid containing processes Electrochem and Biodegradable polymer Innovate UK applications

Papers, Impact and Related 30 papers 2016 / 2017, bringing iPRD total 105 (all named on the web-site) Impact Supported William Blythe with new product CMD project with AZ leading to cost savings Working with company to commercialise Freactors Licensing patents on control system and supported catalyst Front cover of React. Chem. Eng. Richard Bourne named “Emerging Investigator” by React. Chem. Eng. 3 iPRD PDRAs won prizes at School of Chemistry post-doc conference Attendance at (too many to mention) conferences Involved in BioEnergy and CP3 CDTs.

Selected Papers Simon Doherty, Julian G. Knight, Tom Backhouse, Einas Abood, Hind Alshaikh, Ian J. S. Fairlamb, Richard Bourne, Thomas W. Chamberlain and Rebecca Stones, “Highly efficient aqueous phase chemoselective hydrogenation of α,β-unsaturated aldehydes, ketones, esters and nitriles catalysed by palladium nanoparticles stabilised with phosphine-decorated polymer immobilised ionic liquids.” GREEN CHEM., 2017, 19, 1635-1641 Katharina G. Hugentobler, Marcello Rasparini, Lisa A. Thompson, Katherine E. Jolley, A. John Blacker and Nicholas J. Turner “Comparison of a batch and flow approach for the lipase catalysed resolution of a cyclopropanecarboxylate ester; a key building block for the synthesis of ticagrelor.” ORG. PROCESS RES. DEV., 2017, 21, 195-199 Ilias K. Stamatiou and Frans L. Muller, “Determination of mass transfer resistances of fast reactions in three-phase mechanically agitated slurry reactors.” AIChE J., 2017, 63, 273-282 Christopher A. Hone, Nicholas Holmes, Geoffrey R. Akien, Richard A. Bourne and Frans L. Muller, “Rapid multistep kinetic model generation from transient flow data.” REACT. CHEM. ENG., 2017, 2, 103-108 Yuhan Zhao, Georgina King, Maria H. T. Kwan and A. John Blacker, "A mild and selective method for the catalytic hydrodeoxygenation of cyanurate activated phenols in multiphasic continuous flow." ORG. PROC. RES. DEV., 2016, 20, 2012-2018\ Tarn C. Johnston and Stephen P. Marsden, “Precious-metal-free heteroarylation of azlactones:direct synthesis of α-substituted amino acid derivatives.” ORG. LETT., 2016, 18, 5364-5367 Carlo Sambiagio, Rachel H. Munday, A. John Blacker, Stephen P. Marsden and Patrick C. McGowan, “Green alternative solvents for the copper-catalysed arylation of phenols and amides.” RSC ADV., 2016, 6, 70025-70032  Michael R. Chapman, Maria H. T. Kwan, Georgina E. King, Benjamin A. Kyffin, A. John Blacker, Charlotte E. Willans and Bao N. Nguyen, “Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions.” GREEN CHEM., 2016, 18, 4623-4627 Nicholas Holmes, Geoffrey R. Akien, A. John Blacker, Robert L. Woodward, Rebecca E. Meadows and Richard A. Bourne, “Self-optimisation of the final stage in the synthesis of EGFR kinase inhibitor AZD9291 using an automated flow reactor.” REACT. CHEM. ENG., 2016, 1, 366-371 Patricia Marcé, James Lynch, A. John Blacker and Jonathan M. J. Williams, “Conversion of nitroalkanes into carboxylic acids via iodide catalysis in water,” CHEM. COMMUN., 2016, 52, 1013-1016 Nicholas Holmes, Geoffrey R. Akien, Robert J. D. Savage, Christian Stanetty, Ian R. Baxendale, A. John Blacker, B. A. Taylor, Robert L. Woodward, Rebecca E. Meadows and Richard A. Bourne, “Online quantitative mass spectroscopy for the rapid adaptive optimisation of automated flow reactors,” REACT. CHEM. ENG., 2016, 1, 96-100

Plans Close down MSc in Chemical Process R&D Expand Centre for Manufacturability Design Grow expertise in Industrial Biotechnology Continue with Innovate UK and EPSRC and EU applications

Thank You Acknowledgements