Cocaine-induced changes in CNS dopamine release

Slides:



Advertisements
Similar presentations
Main Menu Salas, Hille, Etgen Calculus: One and Several Variables Copyright 2007 © John Wiley & Sons, Inc. All rights reserved. The Indeterminate Form.
Advertisements

Synthesis and receptor interactions of active peptides generated by the kallikrein-kinin and renin-angiotensin systems. Bradykinin is generated by the.
Pharmacogenetics of warfarin dosing
Schematic diagram of idealized regimens using exogenous gonadotropins for fertility induction. A. Step-up regimen for ovulation induction. After menses,
Pharmacogenetics of warfarin dosing
(Adapted, with permission, from Fagin JA
The Distek 2100B United States Pharmacopeia automated dissolution system. (Image used permission from Distek, Inc.) Source: Solubility, Dissolution, and.
Consumer Reports' Statin list comparing efficacy and costs
The β adrenergic receptor (βAR)
Algorithm for troubleshooting external ventricular drain (EVD) blockage. CSF, cerebrospinal fluid; NS, normal saline; CT, computed tomography; EVD, external.
Reproduced from Hadzic A
Reproduced from Hadzic A
Adapted from Weiss et al. J Am Coll Cardiol. 1998;31:
Comparative success of therapy with proton pump inhibitors and H2 receptor antagonists. Data show the effects of a proton pump inhibitor (given once daily)
Treatment algorithm for management of type 2 diabetes mellitus
Sites of action of antifungal drugs
Diagnostic algorithm for normocytic anemia.
Receptor occupancy and clinical response for antipsychotic agents
Cardiac excitation-contraction coupling and its regulation by positive inotropic drugs. The cardiac cycle is initiated by membrane depolarization, which.
Using the prosthesis as an assisting hand
Two PALL epidural filters in series (East Hills, NY )
Negative-feedback control systems
Interrelationships among renal function, Na+ intake, water homeostasis, distribution of extracellular fluid volume, and mean arterial blood pressure. Pathophysiological.
B. Major regulatory effects of ovarian steroids on hypothalamic-pituitary function. Estrogen decreases the amount of follicle-stimulating hormone (FSH)
Internal hemorrhoids. (Used, with permission, from John Cello, MD.)
Schematic wiring diagram of the basal ganglia
Scaphoid fracture. A. Scaphoid fracture nonunion. B
Source: Dizziness, Symptom to Diagnosis: An Evidence-Based Guide, 3e
Structure and function of voltage-gated Na+ channels. A
Proposed pathogenesis of inflammatory bowel disease and target sites for pharmacological intervention. Shown are the interactions among bacterial antigens.
Hill’s proposed force–velocity curve
The prescription. The prescription must be accurately and legibly prepared to identify the patient, the medication to be dispensed, and the mode of drug.
Bioavailability of a drug from an immediate-release tablet containing 50 mg of drug given at 0, 4, and 8 hours compared to a single 150-mg drug dose given.
Location of CYPs in the cell
Mechanism of action of cocaine and amphetamine on synaptic terminal of dopamine (DA) neurons. Left: Cocaine inhibits the dopamine transporter (DAT), decreasing.
Clinical use of PAH drugs based on functional class
Chemical structure of eteplirsen (Drugbank Accession Number: DB06014);43 IUPAC chemical name: (P-deoxy-P-(dimethylamino)](2',3'-dideoxy-2',3'-imino-2',3'-seco)(2'a→5')(C-m5U-C-C-A-A-C-A-m5U-C-A-A-G-G-A-A-G-A-m5U-G-G-C-A-m5U-m5U-m5U-C-m5U-A-G),5'-(P-(4-((2
Mechanisms of opiate action in producing analgesia
Malaria-endemic countries. A. Eastern Hemisphere; B. Western Hemisphere. A country is shaded orange even if malaria is endemic in just a portion of that.
Dose-response relationships. A
Structure and function of blinatumomab. A
Pathways regulating autophagy
Therapeutic injection site on the medial heel for plantar fasciitis
Mechanisms of action of established and experimental drugs used for the chemotherapy of mycobacterial infections. Approved drugs for the chemotherapy of.
Principle of ion exchange in drug delivery systems
Sites of action of hematopoietic growth factors in the differentiation and maturation of marrow cell lines. A self-sustaining pool of marrow stem cells.
Copyright © The McGraw-Hill Companies, Inc
P.W. Kalivas, N. Volkow, J. Seamans  Neuron 
Critiquing Cryos by Morie Gertz Blood Volume 111(11):
Copyright © 2014 John Wiley & Sons, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Assignment Pages: 10 – 12 (Day 1) Questions over Assignment? # 1 – 4
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Page 535 Advanced Engineering Mathematics by Erwin Kreyszig
General Properties of Radiation
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Page 46a Continued Advanced Engineering Mathematics by Erwin Kreyszig
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Page 274 (1) Advanced Engineering Mathematics by Erwin Kreyszig
Copyright © The McGraw-Hill Companies, Inc
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2014 John Wiley & Sons, Inc. All rights reserved. Chapter 20 Managing the Multinational Financial System Tenth Edition Alan C. Shapiro Multinational.
Copyright © 2014 John Wiley & Sons, Inc. All rights reserved. Chapter 19 Current Asset Management and Short-Term Financing Tenth Edition Alan C. Shapiro.
Partial Differential Equations
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.
Presentation transcript:

Cocaine-induced changes in CNS dopamine release Cocaine-induced changes in CNS dopamine release. Dopamine was measured in the extracellular fluid of the nucleus accumbens of rats after daily injections of cocaine (10 mg/kg, i.p.). The first injection of cocaine produced a modest increase and the last, after 7 days, produced a much greater increase in dopamine release. The first saline injection produced no effect on dopamine levels, whereas the second, given 3 days after 7 days of cocaine injections, produced a significant rise in dopamine, presumably due to conditioning. (Adapted from Kalivas and Duffy, 1990. Copyright © Wiley-Liss, Inc., a subsidiary of John Wiley & Sons, Inc.) Source: Drug Addiction, Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 12e Citation: Brunton LL, Chabner BA, Knollmann BC. Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 12e; 2011 Available at: https://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/1613/bru12_ch24_f002.png&sec=102159691&BookID=1613&ChapterSecID=102159667&imagename= Accessed: October 11, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2025 SlidePlayer.com. Inc. All rights reserved.