Regulatory T Cells and the Immune Aging Process: A Mini-Review

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Regulatory T Cells and the Immune Aging Process: A Mini-Review Gerontology 2014;60:130-137 - DOI:10.1159/000355303 Fig. 1. nTregs accumulate with age, while iTreg numbers decline. The frequency and absolute number of naturally occurring Tregs (both CD4+ and CD8+) increases with advancing age in both humans and mice. In contrast, the inducibility of Tregs from nonregulatory CD4+ and CD8+ precursor cells declines over time. © 2013 S. Karger AG, Basel

Regulatory T Cells and the Immune Aging Process: A Mini-Review Gerontology 2014;60:130-137 - DOI:10.1159/000355303 Fig. 2. The impact of aging on the different functional domains of Tregs. Tregs isolated from young hosts are able to efficiently suppress antigen-presenting cell (APC) activation, T cell proliferation and production of cytokines (IFN-γ, IL-2 and IL-17). Aged Tregs maintain suppressive activity towards APCs, T cell proliferation and IFN-γ production, whereas such aged Tregs are much less efficient in downregulating IL-2 and IL-17 production in neighboring T cells. © 2013 S. Karger AG, Basel