Volume 384, Issue 9961, Pages (December 2014)

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Volume 384, Issue 9961, Pages 2228-2234 (December 2014) Glucagon-like peptide-1 receptor agonist and basal insulin combination treatment for the management of type 2 diabetes: a systematic review and meta-analysis Conrad Eng, MSc, Caroline K Kramer, MD, Prof Bernard Zinman, MD, Dr Ravi Retnakaran, MD The Lancet Volume 384, Issue 9961, Pages 2228-2234 (December 2014) DOI: 10.1016/S0140-6736(14)61335-0 Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 1 Study selection process The Lancet 2014 384, 2228-2234DOI: (10.1016/S0140-6736(14)61335-0) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 2 Meta-analyses of glucagon-like peptide-1 (GLP-1) agonist and basal insulin combination treatment versus other anti-diabetic treatments, comparing HbA1c concentrations Outcomes assessed are: (A) HbA1c (%), (B) HbA1c (%) in studies that compared combination treatment with basal-bolus insulin treatment, (C) proportion of participants with HbA1c ≤7·0% at the end of intervention, and (D) proportion of participants with HbA1c ≤7·0% at the end of intervention in studies that compared combination treatment with basal-bolus insulin treatment. For each estimate, the grey shaded area is the weight of the estimate in proportion to the overall effect. The Lancet 2014 384, 2228-2234DOI: (10.1016/S0140-6736(14)61335-0) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 3 Meta-analyses of glucagon-like peptide-1 (GLP-1) agonist and basal insulin combination treatment versus other anti-diabetic treatments, comparing hypoglycaemia and change in weight Outcomes assessed are (A) hypoglycaemia, (B) hypoglycaemia in studies that compared combination treatment with basal-bolus insulin treatment, (C) change in weight (kg) at the end of intervention, and (D) change in weight (kg) at the end of intervention in studies that compared combination treatment with basal-bolus insulin treatment. For each estimate, the grey shaded area is the weight of the estimate in proportion to the overall effect. The Lancet 2014 384, 2228-2234DOI: (10.1016/S0140-6736(14)61335-0) Copyright © 2014 Elsevier Ltd Terms and Conditions