Volume 32, Issue 9, Pages (September 2012)

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Volume 32, Issue 9, Pages 701-708 (September 2012) Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet Morten Møller Poulsen, Jens Ø. Larsen, Stephen Hamilton-Dutoit, Berthil F. Clasen, Niels Jessen, Søren K. Paulsen, Thomas N. Kjær, Bjørn Richelsen, Steen B. Pedersen Nutrition Research Volume 32, Issue 9, Pages 701-708 (September 2012) DOI: 10.1016/j.nutres.2012.08.004 Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 1 Change in rat body weight during the experiment. Total body weight changes of rats fed a C (n = 12), an HF (n = 12), or an HFR (n = 12) for 8 weeks. Values represent group means. No significant changes were found between groups when analyzed by 1-way ANOVA. However, within each individual group, the weight gains were statistically significant when evaluated by paired t test. Nutrition Research 2012 32, 701-708DOI: (10.1016/j.nutres.2012.08.004) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 2 Histopathology. Representative microscopic appearance of liver sections in rats fed a C (n = 12), an HF (n = 12), or an HFR (n = 12) for 8 weeks. In C, minimal steatosis; in HF, extensive periportal small droplet steatosis; and in HFR, essentially no steatosis. Masson trichrome staining, magnification ×400. Nutrition Research 2012 32, 701-708DOI: (10.1016/j.nutres.2012.08.004) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 3 Liver triglyceride content. Liver triglyceride content was determined by ethanolic potassium hydroxide saponification followed by assay for glycerol after an 8-week treatment. C: n = 12, HF: n = 12, HFR: n = 12. Values are group means, with vertical bars indicating SEM. Individual-group comparisons evaluated by Student t test. Nutrition Research 2012 32, 701-708DOI: (10.1016/j.nutres.2012.08.004) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 4 Uncoupling protein 2 mRNA expression. Liver UCP2 mRNA expression relative to 18S mRNA evaluated by reverse transcriptase PCR after an 8-week treatment. C: n = 12, HF: n = 12, HFR: n = 12. Values are group means, with vertical bars indicating SEM. Individual-group comparisons evaluated by Student t test. Nutrition Research 2012 32, 701-708DOI: (10.1016/j.nutres.2012.08.004) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 5 Mitochondria content. Liver mitochondria count quantified as relative expression of mitochondrial DNA, D-loop, relative to nonmitochondrial 18S DNA assessed by reverse transcriptase PCR after an 8- week treatment. C: n = 12, HF: n = 12, HFR: n = 12. Values are group means, with vertical bars indicating SEM. Individual-group comparisons evaluated by Student t test. Nutrition Research 2012 32, 701-708DOI: (10.1016/j.nutres.2012.08.004) Copyright © 2012 Elsevier Inc. Terms and Conditions