Volume 17, Issue 4, Pages (April 2015)

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Volume 17, Issue 4, Pages 392-402 (April 2015) Safety and biodistribution study of bone marrow–derived mesenchymal stromal cells and mononuclear cells and the impact of the administration route in an intact porcine model Tuomas Mäkelä, Reijo Takalo, Oiva Arvola, Henri Haapanen, Fredrik Yannopoulos, Roberto Blanco, Lauri Ahvenjärvi, Kai Kiviluoma, Erja Kerkelä, Johanna Nystedt, Tatu Juvonen, Petri Lehenkari Cytotherapy Volume 17, Issue 4, Pages 392-402 (April 2015) DOI: 10.1016/j.jcyt.2014.12.004 Copyright © 2015 International Society for Cellular Therapy Terms and Conditions

Figure 1 Posterior whole-body gamma camera images were acquired using clinical grade equipment, as described in Methods. The images are representations of IV or IA administration of either BM-MSC or BM-MNC. Lungs and kidneys are clearly visible in all animals, but some clear anatomic differences in the biodistribution can be observed visually between organs, especially bone. Cytotherapy 2015 17, 392-402DOI: (10.1016/j.jcyt.2014.12.004) Copyright © 2015 International Society for Cellular Therapy Terms and Conditions

Figure 2 Volumetric SPECT-CT analysis of accumulated cells in the lungs and bone was analyzed at 8 h. The ROIs were drawn in all slices presenting desired anatomic sites and combined to form a volume of interest, which is presented in the images. (A) Range bars demonstrate the range of lung accumulation. (B) A similar analysis was performed for the L3 and L5 vertebrae. Cytotherapy 2015 17, 392-402DOI: (10.1016/j.jcyt.2014.12.004) Copyright © 2015 International Society for Cellular Therapy Terms and Conditions

Figure 3 SPECT/CT image of an animal without atelectasis (A) with a typical dorsal prominence of BM-MSC accumulation 8 h after transplantation, as indicated by the arrowhead. (B) The corresponding image of an animal with a large atelectasis in the left lung with high activity (arrow). Cytotherapy 2015 17, 392-402DOI: (10.1016/j.jcyt.2014.12.004) Copyright © 2015 International Society for Cellular Therapy Terms and Conditions

Figure 4 Pulmonary artery systolic (A) and diastolic (B) pressure after cell administration. Curves of each individual pig are arranged by study group. Cytotherapy 2015 17, 392-402DOI: (10.1016/j.jcyt.2014.12.004) Copyright © 2015 International Society for Cellular Therapy Terms and Conditions