Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome Marc Pineton de Chambrun, MD, Marie Gousseff, MD, Wladimir Mauhin, MD, Jean-Christophe Lega, MD, PhD, Marc Lambert, MD, PhD, Sophie Rivière, MD, Antoine Dossier, MD, Marc Ruivard, MD, PhD, François Lhote, MD, Gilles Blaison, MD, Laurent Alric, MD, PhD, Christian Agard, MD, PhD, David Saadoun, MD, PhD, Julie Graveleau, MD, Martin Soubrier, MD, PhD, Marie-Josée Lucchini-Lecomte, MD, Christine Christides, MD, Annick Bosseray, MD, Hervé Levesque, MD, PhD, Jean-François Viallard, MD, PhD, Nathalie Tieulie, MD, Pierre-Yves Lovey, MD, Sylvie Le Moal, MD, Béatrice Bibes, MD, Giuseppe Malizia, MD, Pierre Abgueguen, MD, François Lifermann, MD, Jacques Ninet, MD, PhD, Pierre-Yves Hatron, MD, Zahir Amoura, MD, MSc Marc Pineton de Chambrun, Marie Gousseff, Wladimir Mauhin, Arnaud Hot, Laurent Argaud, Romain Hernu, Sylvie de la Salle, Jean-Christophe Lega, Stanislas Ledochowski, Marc Lambert, Anne-Sophie Moreau, Sophie Rivière, Antoine Dossier, Thomas Papo, Romain Sonneville, Marc Ruivard, François Lhote, Bruno Verdière, Gilles Blaison, Sybille Merceron, Nathalie Zappella, Laurent Alric, Christian Agard, Mickael Landais, Nicolas Limal, Damien Contou, David Saadoun, Thomas Similowski, Alexandre Demoule, Thomas Similowski, Julie Graveleau, Martin Soubrier, Bertrand Souweine, Julien Haroche, Julien Boileau, Marie-Josée Lucchini-Lecomte, Bernard Lecomte, Thomas Hanslik, Antoine Vieillard-Baron, Christine Christides, Annick Bosseray, Nicolas Terzi, Hervé Levesque, Caroline Bulte, Aline Talasczka, Eric Hachulla, Olivier Decaux, Florent Ibouanga, Bertrand Arnulf, Matthieu Groh, Elie Azoulay, Marcel Benedit, Jean-François Viallard, Nathalie Tieulie, Assaad Maalouf, Bruno Moulin, Fleur Cohen-Aubart, Pierre-Yves Lovey, Raymond Friolet, Sylvie le Moal, Béatrice Bibes, Micheline Pha, Georges-Etienne Rivard, Eric Rondeau, Giuseppe Malizia, Philippe Debourdeau, Marc Puidupin, Pierre Abgueguen, François Beloncle, Jérôme Devaquet, Claire Presne, François Liferman, Jean-Marc Mazou, Maude Andrieu, Sylvie Paulus, Yannick Fedun, Jean-Paul Mira, Jean-Herlé Raphalen, Oscar Len Abad, Hervé Devilliers, Alister Rogers, Pascal Godmer, Charles-Edouard Luyt, Alain Combes, Miguel Hie, Alexis Mathian, Pierre-Yves Hatron, Jacques Ninet, Zahir Amoura Marc Pineton de Chambrun, MD, Marie Gousseff, MD, Wladimir Mauhin, MD, Jean-Christophe Lega, MD, PhD, Marc Lambert, MD, PhD, Sophie Rivière, MD, Antoine Dossier, MD, Marc Ruivard, MD, PhD, François Lhote, MD, Gilles Blaison, MD, Laurent Alric, MD, PhD, Christian Agard, MD, PhD, David Saadoun, MD, PhD, Julie Graveleau, MD, Martin Soubrier, MD, PhD, Marie-Josée Lucchini-Lecomte, MD, Christine Christides, MD, Annick Bosseray, MD, Hervé Levesque, MD, PhD, Jean-François Viallard, MD, PhD, Nathalie Tieulie, MD, Pierre-Yves Lovey, MD, Sylvie Le Moal, MD, Béatrice Bibes, MD, Giuseppe Malizia, MD, Pierre Abgueguen, MD, François Lifermann, MD, Jacques Ninet, MD, PhD, Pierre-Yves Hatron, MD, Zahir Amoura, MD, MSc Marc Pineton de Chambrun, Marie Gousseff, Wladimir Mauhin, Arnaud Hot, Laurent Argaud, Romain Hernu, Sylvie de la Salle, Jean-Christophe Lega, Stanislas Ledochowski, Marc Lambert, Anne-Sophie Moreau, Sophie Rivière, Antoine Dossier, Thomas Papo, Romain Sonneville, Marc Ruivard, François Lhote, Bruno Verdière, Gilles Blaison, Sybille Merceron, Nathalie Zappella, Laurent Alric, Christian Agard, Mickael Landais, Nicolas Limal, Damien Contou, David Saadoun, Thomas Similowski, Alexandre Demoule, Thomas Similowski, Julie Graveleau, Martin Soubrier, Bertrand Souweine, Julien Haroche, Julien Boileau, Marie-Josée Lucchini-Lecomte, Bernard Lecomte, Thomas Hanslik, Antoine Vieillard-Baron, Christine Christides, Annick Bosseray, Nicolas Terzi, Hervé Levesque, Caroline Bulte, Aline Talasczka, Eric Hachulla, Olivier Decaux, Florent Ibouanga, Bertrand Arnulf, Matthieu Groh, Elie Azoulay, Marcel Benedit, Jean-François Viallard, Nathalie Tieulie, Assaad Maalouf, Bruno Moulin, Fleur Cohen-Aubart, Pierre-Yves Lovey, Raymond Friolet, Sylvie le Moal, Béatrice Bibes, Micheline Pha, Georges-Etienne Rivard, Eric Rondeau, Giuseppe Malizia, Philippe Debourdeau, Marc Puidupin, Pierre Abgueguen, François Beloncle, Jérôme Devaquet, Claire Presne, François Liferman, Jean- Marc Mazou, Maude Andrieu, Sylvie Paulus, Yannick Fedun, Jean-Paul Mira, Jean-Herlé Raphalen, Oscar Len Abad, Hervé Devilliers, Alister Rogers, Pascal Godmer, Charles-Edouard Luyt, Alain Combes, Miguel Hie, Alexis Mathian, Pierre-Yves Hatron, Jacques Ninet, Zahir Amoura The American Journal of Medicine Volume 130, Issue 10, Pages 1219.e19-1219.e27 (October 2017) DOI: 10.1016/j.amjmed.2017.05.023 Copyright © 2017 Elsevier Inc. Terms and Conditions
Figure 1 Treatment administration distribution in 65 patients with monoclonal gammopathy-associated systemic capillary-leak syndrome. The American Journal of Medicine 2017 130, 1219.e19-1219.e27DOI: (10.1016/j.amjmed.2017.05.023) Copyright © 2017 Elsevier Inc. Terms and Conditions
Figure 2 Kaplan-Meier curve of cumulative probability of survival in 65 patients with monoclonal gammopathy-associated systemic capillary-leak syndrome. The American Journal of Medicine 2017 130, 1219.e19-1219.e27DOI: (10.1016/j.amjmed.2017.05.023) Copyright © 2017 Elsevier Inc. Terms and Conditions
Figure 3 Kaplan-Meier curve of cumulative probability of survival in 65 patients with monoclonal gammopathy-associated systemic capillary-leak syndrome with or without preventive treatment with intravenous immunoglobulin. Probabilities of survival were compared using the log rank test. IVIg + = patients treated with intravenous immunoglobulin; IVIg − = patients not treated with intravenous immunoglobulin. The American Journal of Medicine 2017 130, 1219.e19-1219.e27DOI: (10.1016/j.amjmed.2017.05.023) Copyright © 2017 Elsevier Inc. Terms and Conditions