A clinically practicable diagnostic score for metabolic syndrome improves its predictivity of diabetes mellitus: The Gruppo Italiano per lo Studio della.

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Presentation transcript:

A clinically practicable diagnostic score for metabolic syndrome improves its predictivity of diabetes mellitus: The Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico (GISSI)–Prevenzione scoring Alejandro Macchia, MD, Giacomo Levantesi, MD, Giovanna Borrelli, MSc, Maria Grazia Franzosi, MSc, Aldo Pietro Maggioni, MD, RosaMaria Marfisi, MS, Marco Scarano, MSc, Luigi Tavazzi, MD, Gianni Tognoni, MD, Franco Valagussa, MD, Roberto Marchioli, MD American Heart Journal Volume 151, Issue 3, Pages 754.e7-754.e17 (March 2006) DOI: 10.1016/j.ahj.2005.10.023 Copyright © 2006 Mosby, Inc. Terms and Conditions

Figure 1 Observed, predicted risk of diabetes, and distribution of patients according to the score for diagnosis of MS. Solid circles (•) and the gray line indicate the distribution of patients according to progressively increasing values of the score. Solid (♦) diamonds indicate the observed proportion of patients with diagnosis of diabetes during follow-up. The black line indicates the expected incidence of diabetes using the score points. American Heart Journal 2006 151, 754.e7-754.e17DOI: (10.1016/j.ahj.2005.10.023) Copyright © 2006 Mosby, Inc. Terms and Conditions

Figure 2 Receiver-operating characteristic curves showing the performance of the various diagnostic tools in predicting diabetes. Separate plots were used to compare the final model with the original variables to the global risk assessment score used as a continuous variable, the MS-Score and the MS-ATP diagnostic criteria. □ = final model; ▴ = global risk assessment score; ♦ = MS-ATP; • = MS-Score. American Heart Journal 2006 151, 754.e7-754.e17DOI: (10.1016/j.ahj.2005.10.023) Copyright © 2006 Mosby, Inc. Terms and Conditions

Figure 3 Diabetes-free survival of patients attributed to MS-ATP and MS-Score risk groups predicted by a multivariate model. As compared with 3523 patients without MS according to both MS-ATP and MS-Score criteria (incidence of diabetes 6.8%, RR 1.00), 896 were diagnosed as having MS according to ATP-III criteria but not with the MS-Score (incidence of diabetes 8.0%, RR 1.20, 95% CI 0.92-1.56, P = .18), 1214 were diagnosed as having MS according to MS-Score but not with the ATP III criteria (incidence of diabetes 17.8%, RR 2.84, 95% CI 2.36-3.42, P < .0001), and 1835 had an MS diagnosis according to both diagnostic criteria (incidence of diabetes 22.6%, RR 3.68, 95% CI 3.14-4.32, P < .0001). American Heart Journal 2006 151, 754.e7-754.e17DOI: (10.1016/j.ahj.2005.10.023) Copyright © 2006 Mosby, Inc. Terms and Conditions

Figure 4 Incidence, relative risk, and 95% CI for risk of diabetes, death, and death plus diabetes according to the MS-Score and the MS-ATP diagnostic criteria. American Heart Journal 2006 151, 754.e7-754.e17DOI: (10.1016/j.ahj.2005.10.023) Copyright © 2006 Mosby, Inc. Terms and Conditions