Intro to CNS Drugs By Alaina darby

Which of the following is part of the diencephalon? Hypothalamus Medulla Pons Basal ganglia a

Which of the following is not part of the limbic system? Amygdala Mammillary bodies Substantia nigra Orbitofrontal cortex c

Which of the following is properly paired? Cingulate cortex – memory Hippocampus – autonomic, endocrine Nucleus accumbens – spatial memory Cingulate cortex – autonomic, attention, cognition d

Which of the following portions of the brain is responsible for sleep, wakefulness, arousal and eye movements? Thalamus Hypothalamus Midbrain Basal ganglia c

What is the main role of the basal ganglia? Emotion Learning Motor control Cognition c

Which of the following types of channels are not found in neurons? Mechanosensitive channels Voltage gated channels Cyclic nucleotide gated channels Ligand gated channels a

Which of the following is a peptide neurotransmitter? Endocannabinoid GABA Norepinephrine Neurotensin d

Which of the following is true? Metabotropic receptors rely on second messengers Ionotropic receptors have 7 transmembrane domains Metabotropic receptors are transmembrane channels Ionotropic receptors open or close in response to ions a

Which of the following does not directly influence the synthesis or metabolism of dopamine? COMT Reserpine MAO L-DOPA b

Black widow spider venom Nicotine Reserpine Cocaine Which of the following would be considered a form of neurotransmitter antagonism? Black widow spider venom Nicotine Reserpine Cocaine c

Which of the following would result in neurotransmitter agonism? Drug blocks autoreceptors Drug inactivates synthetic enzyme Drug prevents storage of neurotransmitter in vesicles Drug blocks postsynaptic receptors a

Which of the following is not a primary use of stimulants? Anorexic Treatment for ADHD Antiemetic Treatment for narcolepsy c

Which of the following is true of cocaine? Crack is the powder form of the drug It can act as a local anesthetic It causes hypotension It causes the release of neurotransmitter b

Which of the following is more potent than cocaine? Benzoyleconine Cocaethylene Benzoic acid Dexeconine b

Which of the following is the reward portions of the brain takes over in substance abuse? Prefrontal cortex Nucleus accumbens VTA Basal ganglia b

John is 53 and has just been diagnosed with ADHD John is 53 and has just been diagnosed with ADHD. He became addicted to cocaine when he was younger but has since been able to quit. Which of the following drugs is best suited for him? Amphetamine Methylphenidate Atomoxetine Lisdexamfetamine c

Which of the following is a true comparison of mazindol and cocaine? Mazindol is more selective for norepinephrine Cocaine is more selective for norepinephrine Cocaine causes neurotransmitter release while mazindol causes transporter blockade Mazindol causes neurotransmitter release while cocaine causes transporter blockade a

Steve is looking to start taking mazindol for his obesity Steve is looking to start taking mazindol for his obesity. Which of his current drugs would not cause an interaction with mazindol? Tranylcypromine Guanethidine Cimetidine Amitriptyline c

Samantha is pregnant. Which of the following stimulants might induce premature labor, if she were to use it? Cocaine Mazindol Amphetamine Methylphenidate a

Which of the following adverse reactions is the most distinguishing for amphetamine among other stimulants? Headache Confusion Neurotoxicity Restlessness c

Which of the following is thought to have the lowest risk of abuse since it causes less of a surge of dopamine? Amphetamine Methamphetamine Lisdexamfetamine Methylphenidate c

Aluminum chloride to increase elimination Jake is on a high dose of amphetamine for his ADHD and accidentally took his medication three times this morning. Which of the following treatments would he not need to treat the described symptoms from this poisoning? Aluminum chloride to increase elimination Sedative for the resulting anxiety Sodium nitroprusside to reduce hypotension Acidification of his urine to neutralize the amphetamine c

How does methylphenidate differ from amphetamine? Side effects Abuse potential Mechanism of action Usefulness for narcolepsy and ADHD c

Casey needs to lose weight before her wedding in a few weeks and has asked her doctor what she could take to increase her weight loss. Which of the following might he prescribe since she will only be taking it for a short time? Modafinil Amphetamine Phentermine Mazindol c

Which of the following would be effective to treat a narcoleptic that has a history of drug abuse? Amphetamine Methylphenidate Modafinil Atomoxetine c

Cardiovascular problems GI problems Frequent headaches Past addiction What might be a reason to select a medication other than modafinil to treat narcolepsy? Cardiovascular problems GI problems Frequent headaches Past addiction c

How does nicotine cause addiction? Blocking dopamine reuptake Acting on the dopaminergic neurons Activating dopamine receptors Blocking presynaptic dopamine receptors b

Which of the following drugs would be least likely to interact with varenicline? Insulin TCA’s Blood thinners Asthma medications b

Which of the following would be most beneficial to someone who is depressed and wants to quit smoking? Nicotine patch Nicotine gum Varenicline Buproprion d

Which is not a mechanism of action for caffeine? Blocking dopamine and norepinephrine reuptake Adenosine receptor antagonism Phosphodiesterase inhibition Increasing dopamine and norepinephrine release a

Which of the following is true of ephedrine? It is used for narcolepsy, depression, and as a bronchodilator It undergoes extensive metabolism in the liver It decreases dopamine and norepinephrine reuptake It may cause hypotension and insomnia a

Which of the following antagonizes the receptor for an inhibitory amino acid neurotransmitter? Nicotine Modafinil Cocaine Strychnine d

How might one treat strychnine poisoning? Aluminum chloride Diazepam Sodium nitroprusside Benztropine b