Volume 106, Pages 26-32 (September 2017) Is small intestinal bacterial overgrowth involved in the pathogenesis of functional dyspepsia?  Georgios Tziatzios, Evangelos J. Giamarellos-Bourboulis, Ioannis S. Papanikolaou, Mark Pimentel, George D. Dimitriadis, Konstantinos Triantafyllou  Medical Hypotheses  Volume 106, Pages 26-32 (September 2017) DOI: 10.1016/j.mehy.2017.07.005 Copyright © 2017 Elsevier Ltd Terms and Conditions

Fig. 1 Mechanisms potentially contributing to functional dyspepsia pathogenesis; CNS: Central Nervous System. Medical Hypotheses 2017 106, 26-32DOI: (10.1016/j.mehy.2017.07.005) Copyright © 2017 Elsevier Ltd Terms and Conditions

Fig. 2 Schematic illustration of small bowel intestinal overgrowth development and functional symptoms generation by molecular mimicry mechanism that may apply to functional dyspepsia pathogenesis. Dotted lines indicate assumed steps in the process. ICC: interstitial cells of Cajal. Medical Hypotheses 2017 106, 26-32DOI: (10.1016/j.mehy.2017.07.005) Copyright © 2017 Elsevier Ltd Terms and Conditions

Fig. 3 Small bowel intestinal overgrowth (SIBO) – dysmotility interplay in functional dyspepsia (FD); ITT: Intestinal Transit Time. Medical Hypotheses 2017 106, 26-32DOI: (10.1016/j.mehy.2017.07.005) Copyright © 2017 Elsevier Ltd Terms and Conditions

Fig. 4 Small bowel intestinal overgrowth (SIBO) might be the “triggering” factor in a series of events causing increased intestinal permeability, intestinal dysmotility and subsequent functional symptom development. Medical Hypotheses 2017 106, 26-32DOI: (10.1016/j.mehy.2017.07.005) Copyright © 2017 Elsevier Ltd Terms and Conditions