Proton Pump Inhibitor Use and the Risk of Small Intestinal Bacterial Overgrowth: A Meta-analysis  Wai–Kit Lo, Walter W. Chan  Clinical Gastroenterology and Hepatology  Volume 11, Issue 5, Pages 483-490 (May 2013) DOI: 10.1016/j.cgh.2012.12.011 Copyright © 2013 AGA Institute Terms and Conditions

Figure 1 Flow diagram depicting the search and selection process. Clinical Gastroenterology and Hepatology 2013 11, 483-490DOI: (10.1016/j.cgh.2012.12.011) Copyright © 2013 AGA Institute Terms and Conditions

Figure 2 Meta-analysis of SIBO risk with PPI use. Clinical Gastroenterology and Hepatology 2013 11, 483-490DOI: (10.1016/j.cgh.2012.12.011) Copyright © 2013 AGA Institute Terms and Conditions

Figure 3 (A) One-study-removed analysis of SIBO risk to assess the single large study effect. (B) Cumulative analysis of SIBO risk to assess the consistency of results over time. (C) Funnel plot of standard error by SIBO risk. Clinical Gastroenterology and Hepatology 2013 11, 483-490DOI: (10.1016/j.cgh.2012.12.011) Copyright © 2013 AGA Institute Terms and Conditions

Figure 4 Subgroup analyses of SIBO risk with PPI use. (A) Subgroup analysis of SIBO risk with PPI use based on SIBO testing modality (duodenal/jejunal aspirate culture vs GHBT). (B) Subgroup analysis based on study design (pretest-posttest/self-control vs separate control). Clinical Gastroenterology and Hepatology 2013 11, 483-490DOI: (10.1016/j.cgh.2012.12.011) Copyright © 2013 AGA Institute Terms and Conditions