Volume 140, Issue 1, Pages (July 2011)

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Volume 140, Issue 1, Pages 117-126 (July 2011) Maintenance Therapy With Continuous or Switch Strategy in Advanced Non-small Cell Lung Cancer Xinji Zhang, PhD, Jiajie Zang, PhD, Jinfang Xu, PhD, Chong Bai, MD, PhD, Yingyi Qin, MASc, Ke Liu, PhD, Cheng Wu, PhD, Meijing Wu, PhD, Qian He, PhD, Shanshan Zhang, PhD, Lixin Wei, PhD, Jia He, PhD CHEST Volume 140, Issue 1, Pages 117-126 (July 2011) DOI: 10.1378/chest.10-2745 Copyright © 2011 The American College of Chest Physicians Terms and Conditions

Figure 1 Identification process for eligible studies. CAI = caboxyaminoimidazole; CCRT = concurrent chemoradiotherapy; HR = hazard ratio; MACC = methotrexate, doxorubicin, cyclophosphamide, and lomustine; MIC = mitomycin-ifosfamide-cisplatin; OS = overall survival; PFS = progression-free survival; RCT = randomized controlled trial; RT = radiation therapy. CHEST 2011 140, 117-126DOI: (10.1378/chest.10-2745) Copyright © 2011 The American College of Chest Physicians Terms and Conditions

Figure 2 Comparison of OS between continuous maintenance therapy and placebo or observation. See Figure 1 legend for expansion of abbreviations. CHEST 2011 140, 117-126DOI: (10.1378/chest.10-2745) Copyright © 2011 The American College of Chest Physicians Terms and Conditions

Figure 3 Comparison of OS between switch maintenance therapy and placebo or observation. See Figure 1 legend for expansion of abbreviations. CHEST 2011 140, 117-126DOI: (10.1378/chest.10-2745) Copyright © 2011 The American College of Chest Physicians Terms and Conditions

Figure 4 Comparison of PFS between continuous maintenance therapy and placebo or observation. See Figure 1 legend for expansion of abbreviations. CHEST 2011 140, 117-126DOI: (10.1378/chest.10-2745) Copyright © 2011 The American College of Chest Physicians Terms and Conditions

Figure 5 Comparison of PFS between switch maintenance therapy and placebo or observation. See Figure 1 legend for expansion of abbreviations. CHEST 2011 140, 117-126DOI: (10.1378/chest.10-2745) Copyright © 2011 The American College of Chest Physicians Terms and Conditions

Figure 6 Summary of drug-related toxicities of grade 3 or greater. Alt = alanine aminotransferase. CHEST 2011 140, 117-126DOI: (10.1378/chest.10-2745) Copyright © 2011 The American College of Chest Physicians Terms and Conditions