Acute Inflammation (recruitment of neutrophils).

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CHRONIC (AND GRANULOMATOUS) INFLAMMATION

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Presentation transcript:

Acute Inflammation (recruitment of neutrophils).

Acute Inflammation

Acute Inflammation

Acute Inflammation

Acute Inflammation (with pus)

Acute Inflammation

Acute Inflammation

Chronic inflammation It is the inflammation of prolong duration (weeks or months). It is occurred as: Following acute inflammation. Occurs, incidentally as active inflammation. With tissue destruction. With repair process.

Chronic Inflammation (Tissue destruction-Pancreas)

Chronic Inflammation (Fibrosis-pancreas)

Causes of Chronic inflammation I - Persistent infection. II - Prolonged exposure to potentially toxic agents. III - Autoimmunity.

Chronic Inflammation (Lung)

Causes of Chronic inflammation I - Persistent infection: Bacteria. Viruses. Fungi. Parasites

Chronic Gastritis

Causes of Chronic inflammation III - Autoimmunity: Occurs in: Rheumatoid arthritis. Lupus erythmatosus.

Chronic Inflammation (Rheumatoid arthritis)

Chronic Inflammation (Rheumatoid arthritis)

Chronic inflammation Lymphocyte, macrophage, plasma cell (mononuclear cell) infiltration Tissue destruction by inflammatory cells Attempts at repair with fibrosis and angiogenesis (new vessel formation) When acute phase cannot be resolved Persistent injury or infection (ulcer, TB) Prolonged toxic agent exposure (silica) Autoimmune disease states (RA, SLE)

Morphological Features of Chronic Inflammation These are characterized by: I - Infiltration by mononuclear cells. II - Tissue destruction. III - Removal of damaged tissue, (healing).

Morphological Features of Chronic Inflammation I - Infiltration by mononuclear cells: The mononuclear cells are become predominant after 48 hours. These include: Macrophages. Lymphocytes. Plasma cells. Eosinophils. Mast cells.

Morphological Features of Chronic Inflammation II - Tissue destruction Occur due to: Inflammatory cells. Persistent infecting material.

Morphological Features of Chronic Inflammation III - Removal of damaged tissue, (healing): Occur by proliferation of small blood vessels, (angiogenesis). Proliferation of fibroblast, (fibrosis-repair).

Granulomatous Inflammation Clusters of T cell-activated macrophages, which engulf and surround indigestible foreign bodies (mycobacteria, H. capsulatum, silica, suture material) Resemble squamous cells, therefore called “epithelioid” granulomas with peripheral lymphocytes, fibrosis & multinucleated giant cells.

Chronic Granulomatous Inflammation

Chronic Granulomatous Inflammation

Chronic Granulomatous Inflammation

Bacterial infection (neutrophilia) Parasitic infection (eosinophilia) Viral infection (lymphocytosis)

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