Anticonvulsants By Alaina Darby

Which of the following is not a type of seizure that is generated from multiple regions on both hemispheres of the brain? Tonic Myoclonic Complex partial Absence (petit mal) c

GABAergic neurotransmission enhancement Screening tests Which of the following is not a mechanism-oriented approach for epilepsy drug development? GABAergic neurotransmission enhancement Screening tests Glutamate neurotransmission inhibition Modification of ion channels b

Improved drug efficacy Which would not be an application for surgical resection or vagus nerve stimulation treatment in epilepsy? Drug resistance Drug intolerance Reduction of drug dose Improved drug efficacy d

Discontinue the phenytoin Stacie has developed diplopia and ataxia after taking phenytoin. What should the doctor do? Adjust her dose down Treat the side effects Change her medication Discontinue the phenytoin a

Amy has been experiencing absence seizures Amy has been experiencing absence seizures. Which of the following would be best for her to take? Carbamazepine Phenobarbital Clonazepam Tiagabine c

Which of the following would be least likely to increase plasma concentrations of warfarin due to plasma protein binding? Tiagabine Phenytoin Valproate Carbamazepine d

Amanda presents to the doctor with hirsutism and gingival hypertrophy Amanda presents to the doctor with hirsutism and gingival hypertrophy. Which of the following AED’s is she taking? Phenytoin Phenobarbital Valproate Vigabatrin a

Which of the following AED’s does not inhibit Na+ channels? Lamotrigine Topiramate Felbamate Zonisamide c

Which of the following AED’s enhances K+ channel function? Rufinamide Felbamate Ezogabine Lacosamide c

Which of the following antagonizes glutamate receptors and can be dosed once per day? Carbamazepine Perampanel Gabapentin Felbamate b

Doug has partial seizures, liver failure, and is taking warfarin Doug has partial seizures, liver failure, and is taking warfarin. Which of the following should he use? Ethosuximide Carbamazepine Valproate Phenytoin b

Kara is pregnant and has generalized tonic-clonic seizures Kara is pregnant and has generalized tonic-clonic seizures. Which of the following could she take? Valproate Phenytoin Topiramate Zonisamide d

Samantha has started having absence seizures Samantha has started having absence seizures. Which of the following would be the drug of choice for this type of seizure? Ethosuximide Valproate Lamotrigine Clonazepam a

Drew is anemic and has partial seizures Drew is anemic and has partial seizures. Which of the following would he be able to take? Topiramate Carbamazepine Felbamate Phenobarbital a

Which of the following would be preferred in status epilepticus? Diazepam Lorazepam Clonazepam Clorazepate b

Which of the following AED’s has no effect on the GABA receptors? Gabapentin Felbamate Topiramate Phenobarbital a

Which of the following AED’s would not be used to treat Lennox-Gastaut syndrome? Lamotrigine Felbamate Lacosamide Rufinamide c

Which of the following is considered a refractory drug for partial seizures due to its side effects of vision loss, blue pigmentation in skin, and bladder dysfunction? Vigabatrin Ezogabine Felbamate Topiramate b

Sally has developed glaucoma Sally has developed glaucoma. Which of the following AED’s was she probably taking? Vigabatrin Ezogabine Felbamate Topiramate d

Which of the following does not cause diplopia and ataxia? Phenytoin Felbamate Carbamazepine Lamotrigine b

Which of the following is not used as an add-on therapy? Pregabalin Perampanel Lacosamide Topiramate d

Valerie is experiencing hair loss, fine tremors, and weight gain Valerie is experiencing hair loss, fine tremors, and weight gain. Which of the following might she be taking? Felbamate Valproate Levetiracetam Vigabatrin b

Which of the following AED’s is not thought to exert its effect by inhibiting glutamate release? Lamotrigine Gabapentin Perampanel Levetiracetam c

Which of the following AED’s does not block sodium channels? Phenytoin Lamotrigine Zonisamide Vigabatrin d

Which of the following should not be taken with erythromycin? Valproate Lamotrigine Carbamazepine Perampanel c

Which of the following does not induce UGT? Phenytoin Lamotrigine Carbamazepine Phenobarbital b

Which of the following would not increase the risk of pregnancy when taken with oral contraceptives? Tigabine Phenytoin Carbamazepine Phenobarbital a

Which of the following does not work by increasing the levels of GABA? Felbamate Tagabine Vigabatrin Valproate a

Which of the following does not cause problems in the eye? Vigabatrin Ezogabine Zonisamide Topimerate c