Fig. 1. CsA blood concentration time curve according to the population model (dashed line), the actual measured CsA blood concentrations at t=0, 2 and 3 h (open circles) and t=1, 4, 6, 8 and 12 h (closed circles) and the CsA blood concentration time curve according to the model (solid line) after fitting the population parameters to the measured concentrations at t=0, 2 and 3 h (open circles) after administration, in a 45‐year‐old female 1 year after renal transplantation. Dose=225/200 mg. From: A compartmental pharmacokinetic model of cyclosporin and its predictive performance after Bayesian estimation in kidney and simultaneous pancreas–kidney transplant recipients Nephrol Dial Transplant. 2003;18(6):1201-1208. doi:10.1093/ndt/gfg065 Nephrol Dial Transplant | European Renal Association–European Dialysis and Transplant Association
Fig. 2. (A) Relationship between C<sub>trough</sub> and AUC calculated with the trapezium rule (golden standard). Relationship between the AUC calculated according to the compartment model with blood concentration time points taken at 0 and 2 h (B) and 0, 2 and 3 h (C) and the golden standard AUC. All relationships are shown for 20 KTA (closed circles) and 20 SPKT (open circles) recipients. The r<sup>2</sup> is based on all 40 patients. From: A compartmental pharmacokinetic model of cyclosporin and its predictive performance after Bayesian estimation in kidney and simultaneous pancreas–kidney transplant recipients Nephrol Dial Transplant. 2003;18(6):1201-1208. doi:10.1093/ndt/gfg065 Nephrol Dial Transplant | European Renal Association–European Dialysis and Transplant Association
Fig. 5. Distribution of residuals vs time in 20 KTA (A and B) and 20 SPKT (C and D) recipients. The concentrations predicted are based on either the whole data set (A and C) or a limited sampling data set of 0, 2 and 3 h (B and D). From: A compartmental pharmacokinetic model of cyclosporin and its predictive performance after Bayesian estimation in kidney and simultaneous pancreas–kidney transplant recipients Nephrol Dial Transplant. 2003;18(6):1201-1208. doi:10.1093/ndt/gfg065 Nephrol Dial Transplant | European Renal Association–European Dialysis and Transplant Association
Fig. 3. (A) Relationship between the AUC according to the LSM with sampling points at 1 and 3 h [7] and the golden standard AUC. (B) Relationship between the AUC according to the LSM with sampling points at 2 and 6 h [6] and the golden standard AUC. All relationships are shown for 20 KTA (solid circles) and 20 SPKT (open circles) recipients. The r<sup>2</sup> is based on all 40 patients. From: A compartmental pharmacokinetic model of cyclosporin and its predictive performance after Bayesian estimation in kidney and simultaneous pancreas–kidney transplant recipients Nephrol Dial Transplant. 2003;18(6):1201-1208. doi:10.1093/ndt/gfg065 Nephrol Dial Transplant | European Renal Association–European Dialysis and Transplant Association
Fig. 4. (A) Relationship between C<sub>2h</sub> and the AUC<sub>0–4h</sub>. (B) Relationship between C<sub>2h</sub> and the AUC<sub>0–12h</sub>. (C) Relationship between the AUC<sub>0–4h</sub> and the AUC<sub>0–12h</sub>. All relationships are shown for 20 KTA (closed circles) and 20 SPKT (open circles) recipients. The r<sup>2</sup> is based on all 40 patients. From: A compartmental pharmacokinetic model of cyclosporin and its predictive performance after Bayesian estimation in kidney and simultaneous pancreas–kidney transplant recipients Nephrol Dial Transplant. 2003;18(6):1201-1208. doi:10.1093/ndt/gfg065 Nephrol Dial Transplant | European Renal Association–European Dialysis and Transplant Association
Fig. 6. (A) CsA blood concentrations measured at 0, 2 and 3 h after drug administration (open circles) and according to the model after fitting (solid line) in a 60‐year‐old stable female KTA recipient (serum creatinine=70 µmol/l; body weight=46 kg). C<sub>0h</sub> was 97 µg/l, the AUC<sub>0–12h</sub> according to the model was 4596 h×µg/l, while the golden standard AUC<sub>0–12h</sub> was 4997 h×µg/l. The dose adjustment was made to achieve a target AUC<sub>0–12h</sub> of 3250 h×µg/l. (B) CsA blood concentrations measured at 0, 2 and 3 h after drug administration (open circles) and according to the model after fitting (solid line) in a 50‐year‐old SPKT recipient (serum creatinine=272 µmol/l; body weight=64 kg). C<sub>0h</sub> was 393 µg/l, AUC<sub>0–12h</sub> according to the model was 7201 h×µg/l, C<sub>1h</sub> was 480 µg/l, C<sub>2h</sub> 744 µg/l and C<sub>3h</sub> 882 µg/l. The AUC<sub>0–12h</sub> according to Wacke et al. [7] was 5004 h×µg/l and according to Amante and Kahan [6] was 7679 h×µg/l, while the golden standard AUC<sub>0–12h</sub> was 7391 h×µg/l. From: A compartmental pharmacokinetic model of cyclosporin and its predictive performance after Bayesian estimation in kidney and simultaneous pancreas–kidney transplant recipients Nephrol Dial Transplant. 2003;18(6):1201-1208. doi:10.1093/ndt/gfg065 Nephrol Dial Transplant | European Renal Association–European Dialysis and Transplant Association