Volume 64, Issue 6, Pages (December 2003)

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Volume 64, Issue 6, Pages 2253-2261 (December 2003) ACE inhibition limits chronic injury of kidney transplant even with treatment started when lesions are established Marina Noris, Marilena Mister, Anna Pezzotta, Nadia Azzollini, Paola Cassis, Ariela Benigni, Elena Gagliardini, Norberto Perico, Giuseppe Remuzzi Kidney International Volume 64, Issue 6, Pages 2253-2261 (December 2003) DOI: 10.1046/j.1523-1755.2003.00318.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Schematic representation of the experimental design. CsA is cyclosporine A. Kidney International 2003 64, 2253-2261DOI: (10.1046/j.1523-1755.2003.00318.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Time course of serum creatinine in the three groups of transplanted rats. Untreated is untreated allograft recipients. Values are the mean ± SE. °P < 0.05 vs. basal and syngeneic; #P < 0.01 vs. trandolapril and syngeneic; *P < 0.01 vs. 7months. Kidney International 2003 64, 2253-2261DOI: (10.1046/j.1523-1755.2003.00318.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3 24-hour urinary protein excretion of the different experimental groups as a function of time after transplant. Untreated is untreated allograft recipients. Values are mean ± SE. °P < 0.05 vs. basal; #P < 0.05 vs. trandolapril and syngeneic; *P < 0.01, +P < 0.05 vs. 7months; §P < 0.05 vs. syngeneic. Kidney International 2003 64, 2253-2261DOI: (10.1046/j.1523-1755.2003.00318.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 4 Glomerular injury in the three groups of transplanted rats at 7months (before start of treatment) and at the end of the 13-month follow-up period. Untreated is untreated allograft recipients. Values are mean ± SE. °P < 0.05 vs. 7months; #P < 0.01 vs. trandolapril and syngeneic; *P < 0.05 vs. syngeneic. Kidney International 2003 64, 2253-2261DOI: (10.1046/j.1523-1755.2003.00318.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 5 Intragraft immunostaining of ED-1+ macrophages, OX6+[major histocompatibility complex class II (MHC II+)] cells, CD8+, and CD4+ lymphocytes in the three groups of transplanted rats at the end of the 13-month follow-up. Untreated is untreated allograft recipients. Values are mean ± SE. °P < 0.05 vs. control. Kidney International 2003 64, 2253-2261DOI: (10.1046/j.1523-1755.2003.00318.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 6 Effect of in vivo administration of trandolapril on T-cell alloreactive response. Lewis rats received a pulse of allogenic Brown-Norway (BN) splenocytes (10 × 106 intravenously.) and were either left untreated (BN spleen) or were treated with trandolapril (BN spleen + trandolapril). Five days later, animals were sacrificed and lymph node cells were isolated. The lymphocyte proliferative response (stimulation index) against donor BN or third-party Wistar Furth (WF) stimulators was assessed in mixed lymphocyte reaction (MLR) in vitro. Spleen is splenocytes. Kidney International 2003 64, 2253-2261DOI: (10.1046/j.1523-1755.2003.00318.x) Copyright © 2003 International Society of Nephrology Terms and Conditions