Multidose Cold Oxygenated Blood Is Superior to a Single Dose of Bretschneider HTK- Cardioplegia in the Pig Tord Fannelop, MD, Geir Olav Dahle, MD, Pirjo-Riitta.

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Presentation transcript:

Multidose Cold Oxygenated Blood Is Superior to a Single Dose of Bretschneider HTK- Cardioplegia in the Pig Tord Fannelop, MD, Geir Olav Dahle, MD, Pirjo-Riitta Salminen, MD, Christian Arvei Moen, Knut Matre, MS, PhD, Arve Mongstad, Finn Eliassen, Leidulf Segadal, MD, PhD, Ketil Grong, MD, PhD The Annals of Thoracic Surgery Volume 87, Issue 4, Pages 1205-1213 (April 2009) DOI: 10.1016/j.athoracsur.2009.01.041 Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Myocardial temperature after the first cardioplegic infusion, at corresponding time points before repeated blood cardioplegia (CBC) and at declamping are shown. Values reported are mean ± standard error of the mean. § and * significant difference from previous value(s) within the Custodiol Bretschneider solution (HTK; filled symbols) group and the multidose cold oxygenated blood cardioplegia (CBC; open symbols) group; # significant difference between groups. The Annals of Thoracic Surgery 2009 87, 1205-1213DOI: (10.1016/j.athoracsur.2009.01.041) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Cardiac index, ejection fraction (EF%), and slopes of preload recruitable stroke work (PRSW) and the end-systolic pressure-volume relations (ESPVR) are shown. Values reported are mean ± standard error of the mean. * significant difference from previous value within the multidose cold oxygenated blood cardioplegia group (open symbols); # significant difference between groups. (filled symbols = Custodiol Bretschneider HTK solution; pg = between groups probability; pi = interaction probability; pw = within groups probability.) The Annals of Thoracic Surgery 2009 87, 1205-1213DOI: (10.1016/j.athoracsur.2009.01.041) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Peak systolic radial strain and tissue blood flow rate in left ventricular anterior wall 1, 2, and 3 hours after declamping are shown. Values reported are mean + standard error of the mean. * significant difference from value to the left within the multidose cold oxygenated blood cardioplegia (CBC; white bars) group; # significant difference between groups. (Epi, Mid, and Endo = subepicardial, midmyocardial, and subendocardial wall layers, respectively; HTK [black bars] = Custodiol Bretschneider solution.) The Annals of Thoracic Surgery 2009 87, 1205-1213DOI: (10.1016/j.athoracsur.2009.01.041) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Serum troponin-T concentrations at baseline and 3 hours after declamping are shown. Values reported are mean + standard error of the mean. § and * significant difference from baseline within the Custodiol Bretschneider solution (HTK; black bars) group and multidose cold oxygenated blood cardioplegia (CBC; white bars) group; # significant difference between groups at corresponding level. The Annals of Thoracic Surgery 2009 87, 1205-1213DOI: (10.1016/j.athoracsur.2009.01.041) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions