Warm-Up (1/12) Describe how a cell differentiates during development. On the piece of white paper from the back, answer the following question. Name Date Period Describe how a cell differentiates during development.

2E.1c: Programmed cell death (apoptosis) plays a role in the normal development and differentiation. Illustrative example: Morphogenesis of fingers and toes 4A.2e: Lysosomes are membrane-enclosed sacs that contain hydrolytic enzymes, which are important in intracellular digestion, the recycling of a cell’s organic materials and programmed cell death (apoptosis). Lysosomes carry out intracellular digestion in a variety of ways. 4A.3c: Environmental stimuli can affect gene expression in a mature cell.

Differentiation through Death 1. Apoptosis = programmed cell death used for normal development. 2. 3.

Apoptosis: Cell Suicide Lysosomes are organelles filled with acid and enzymes which digest cellular waste. Lysosome nucleus

Apoptosis: Cell Suicide Lysosomes are organelles filled with acid and enzymes which digest cellular waste. receptor LYSOSOME ACTIVATOR PROTEIN apoptosis signal P 2nd messenger Lysosome TF nucleus

Apoptosis: Cell Suicide Lysosomes are organelles filled with acid and enzymes which digest cellular waste. receptor apoptosis signal P 2nd messenger Lysosome nucleus

Apoptosis: Cell Suicide Lysosomes are organelles filled with acid and enzymes which digest cellular waste. MR. CELL Lysosome nucleus

Differentiation through Death 1. Cells that are going to die Apoptosis = programmed cell death used for normal development. 2. 3. Cells that did die

Critical Thinking Question #1 Discuss this question with your partner and write or represent it. I will call on three people to share their partners’ answers. Describe how apoptosis plays a role in development.

Critical Thinking Question #2 The model below shows a cell with a receptor that is un- activated. Redraw this model and revise it to show how signals from other cells can promote apoptosis.

2E.1c: Programmed cell death (apoptosis) plays a role in the normal development and differentiation. Illustrative example: Morphogenesis of fingers and toes 4A.2e: Lysosomes are membrane-enclosed sacs that contain hydrolytic enzymes, which are important in intracellular digestion, the recycling of a cell’s organic materials and programmed cell death (apoptosis). Lysosomes carry out intracellular digestion in a variety of ways. 4A.3c: Environmental stimuli can affect gene expression in a mature cell.

Illustrative Example: Melanin Production Environmental stimuli can affect gene expression in a mature cell. cell membrane melanin nucleus RNA UV damage melanin gene

Illustrative Example: Melanin Production Environmental stimuli can affect gene expression in a mature cell. cell membrane melanin nucleus RNA UV damage melanin gene

Closure On the piece of white paper from the back, answer the following question: Name Date Period How do processes occurring in the nucleus affect the lysosome when a cell undergoes apoptosis? Scale 1 – 10