Human Serum Albumin (DB00062) Approved Drug Chemical Formula: C2936H4624N786O110S41 Molecular Weight: 66472.2 Human serum albumin isolated from expired blood plasma Indication/Usage For treatment of severe blood loss, hypervolemia, hypoproteinemia Pharmacodynamics Regulates the colloidal osmotic pressure of blood. It is used to increase the circulating plasma volume, thereby reducing hemoconcentrtion and blood viscosity. Also used as a transport protein that binds naturally occurring, therapeutic and toxic materials in circulation. Mechanism Of Action Acts as a high molecular weight, very soluble osmolyte Category Serum Substitutes Affected Organisms Humans and Mammals.

Experimenatl Properties Sequence MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL Experimenatl Properties Melting Point-62 °C Hydrophobicity: 0.395 Isoelectric Point: 5.67 Targets Apolipoprotein E,Serum amyloid A-1 protein,Protein AMBP Marketed Brands Albuminar: CSL Behring Albutein: GRIFOLS

Albuminar Formulation Used/Prescribed for Dosage Contraindications Albuminar is a sterile aqueous solution of albumin obtained from large pools of adult human venous plasmaby low temperature controlled fractionation according to the Cohn process. It is stabilized with 0.02 M sodium acetyltryptophanate and 0.02 M sodium caprylate and pasteurized at 60°C for 10 hours. Albumin (Human) 25%, is a sterile aqueous solution of albumin obtained from large pools of adult human venous plasma by low temperature controlled fractionation according to the Cohn process. It is to be administered by the intravenous route. Formulation Albumin (Human) 25% (albumin human) is a solution containing in each 100 mL, 25 grams of serum albumin, osmotically equivalent to 500 mL of normal human plasma. The pH of the solution is adjusted with sodium bicarbonate, sodium hydroxide, or acetic acid. Approximate concentrations of significant electrolytes per liter are: sodium - 130-160 mEq; and potassium - n.m.t. 1 mEq. Used/Prescribed for precscribed in treatment of Shock, Burns, Hypoproteinemia with or without edema Dosage Albumin (Human) 25%, Albuminar®-25 (albumin (human)) may be given intravenously without dilution or it may be diluted with normal saline or 5% dextrose before administration. 200 mL per liter gives a solution which is approximately isotonic and iso-osmotic with citrated plasma. Contraindications Albumin (Human) 25% may be contraindicated in patients with severe anemia or cardiac failure and in patients with a history of allergic reactions to human albumin. Side-effects Allergic or pyrogenic reactions are characterized primarily by fever and chills; rash, nausea, vomiting, tachycardia and hypotension have also been reported. if administered rapidly, may result in vascular overload with resultant pulmonary edema..

Albutein References Formulation Used/Prescribed for Dosage http://www.rxlist.com/albuminar-drug.htm Albutein Albutein is a concentrate of plasma proteins from human blood. It works by increasing plasma volume or serum albumin levels. Albutein® 20% is a sterile, aqueous solution for single dose intravenous administration containing 20% human albumin (weight/volume). Formulation Albutein® 20% is clinically desirable, compatible diluents include sterile 0.9% Sodium Chloride solution or sterile 5% Dextrose in Water. Used/Prescribed for For treatment of hypovolemic shock,As an adjunct in hemodialysis for patients undergoing long-term dialysis or for those patients who are fluid-overloaded and cannot tolerate substantial volumes of salt solution for therapy of shock or hypotension Dosage Albutein® 20% is administered intravenously. The total dosage will vary with the individual. In adults, an initial infusion of 100 mL is suggested.  Contraindications Albutein® 20% is contraindicated in patients with severe anemia or cardiac failure in the presence of normal or increased intravascular volume. Side-effects The most common adverse reactions include fever and chills, rash, nausea, vomiting, tachycardia and hypotension. Should an adverse reaction occur, slow or stop the infusion for a short period of time which may result in the disappearance of the symptoms. If administration has been stopped and the patient requires additional Albutein® 20%, material from a different lot should be used.

References Peters, T., Jr., Serum Albumin in: The Plasma Proteins, 2nd Ed., Putnam F.W. (ed), New York, Academic Press, 1:133-181, 1975. Finlayson, J.S., Albumin Products Semin Thromb Hemo, 6:85-120, 1980.