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Copyright © 2002 American Medical Association. All rights reserved. From: Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications JAMA. 2002;288(20):2579-2588. doi:10.1001/jama.288.20.2579 Figure Legend: AGE indicates advanced glycation endproduct; oxLDL, oxidized low-densitylipoprotein; GSH, glutathione; GSSG, glutathione disulfide; and NADPH, nicotinamide-adeninedinucleotide phosphate. Date of download: 10/11/2017 Copyright © 2002 American Medical Association. All rights reserved.

Copyright © 2002 American Medical Association. All rights reserved. From: Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications JAMA. 2002;288(20):2579-2588. doi:10.1001/jama.288.20.2579 Date of download: 10/11/2017 Copyright © 2002 American Medical Association. All rights reserved.

Copyright © 2002 American Medical Association. All rights reserved. From: Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications JAMA. 2002;288(20):2579-2588. doi:10.1001/jama.288.20.2579 Figure Legend: NADPH indicates reduced nicotinamide-adenine dinucleotide phosphate;NADP+, oxidized nicotinamide-adenine dinucleotide phosphate; NAD+, oxidized nicotinamide adenine dinucleotide; and NADH, reduced nicotinamideadenine dinucleotide. Date of download: 10/11/2017 Copyright © 2002 American Medical Association. All rights reserved.

Copyright © 2002 American Medical Association. All rights reserved. From: Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications JAMA. 2002;288(20):2579-2588. doi:10.1001/jama.288.20.2579 Figure Legend: AR indicates aldose reductase; RAGE, receptor for advanced glycationendproducts; PKC, protein kinase C. Date of download: 10/11/2017 Copyright © 2002 American Medical Association. All rights reserved.

Copyright © 2002 American Medical Association. All rights reserved. From: Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications JAMA. 2002;288(20):2579-2588. doi:10.1001/jama.288.20.2579 Figure Legend: OXPHOS indicates oxidative phosphorylation; ROI, reactive oxygenintermediate; AGE, advanced glycation endproduct; and NADPH, nicotinamide-adeninedinucleotide phosphate. Date of download: 10/11/2017 Copyright © 2002 American Medical Association. All rights reserved.